Interleukin-6: A promising cytokine to support liver regeneration and adaptive immunity in liver pathologies
Liver pathologies (fibrosis, cirrhosis, alcoholic, non-alcoholic diseases and hepatocellular
carcinoma) represent one of the most common causes of death worldwide. A number of …
carcinoma) represent one of the most common causes of death worldwide. A number of …
[HTML][HTML] Fibrinogen-like protein 2 aggravates nonalcoholic steatohepatitis via interaction with TLR4, eliciting inflammation in macrophages and inducing hepatic lipid …
J Hu, H Wang, X Li, Y Liu, Y Mi, H Kong, D Xi, W Yan… - Theranostics, 2020 - ncbi.nlm.nih.gov
Rationale: The functions of fibrinogen-like protein 2 (fgl2) have been studied in many
inflammatory and neoplastic diseases, but the role of fgl2 in nonalcoholic fatty liver disease …
inflammatory and neoplastic diseases, but the role of fgl2 in nonalcoholic fatty liver disease …
Acetaminophen-induced liver injury alters expression and activities of cytochrome P450 enzymes in an age-dependent manner in mouse liver
Drug-induced liver injury (DILI) is a global medical problem. The risk of DILI is often related
to expression and activities of drug-metabolizing enzymes, especially cytochrome P450s …
to expression and activities of drug-metabolizing enzymes, especially cytochrome P450s …
Alterations of Cytochrome P450–Mediated Drug Metabolism during Liver Repair and Regeneration after Acetaminophen-Induced Liver Injury in Mice
Acetaminophen (APAP)-induced liver injury (AILI) is the leading cause of acute liver failure
in the United States, but its impact on metabolism, therapeutic efficacy, and adverse drug …
in the United States, but its impact on metabolism, therapeutic efficacy, and adverse drug …
Chronic IL-6 administration desensitizes IL-6 response in liver, causes hyperleptinemia and aggravates steatosis in diet-induced-obese mice
AL Gavito, D Bautista, J Suarez, S Badran, R Arco… - PloS one, 2016 - journals.plos.org
High-fat diet-induced obesity (DIO) is associated with fatty liver and elevated IL-6 circulating
levels. IL-6 administration in rodents has yielded contradictory results regarding its effects on …
levels. IL-6 administration in rodents has yielded contradictory results regarding its effects on …
Acetaminophen-induced liver injury alters the acyl ethanolamine-based anti-inflammatory signaling system in liver
Protective mechanisms against drug-induced liver injury are actively being searched to
identify new therapeutic targets. Among them, the anti-inflammatory N-acyl ethanolamide …
identify new therapeutic targets. Among them, the anti-inflammatory N-acyl ethanolamide …
D-chiro-inositol treatment affects oocyte and embryo quality and improves glucose intolerance in both aged mice and mouse models of polycystic ovarian syndrome
E Pericuesta, R Laguna-Barraza… - International Journal of …, 2020 - mdpi.com
Polycystic ovarian syndrome (PCOS) is the main cause of female infertility. It is a
multifactorial disorder with varying clinical manifestations including metabolic/endocrine …
multifactorial disorder with varying clinical manifestations including metabolic/endocrine …
The adiponectin promoter activator NP-1 induces high levels of circulating TNFα and weight loss in obese (fa/fa) Zucker rats
Chronic NP-1 administration reduces body weight and hepatic steatosis despite induction of
tolerance in adiponectin gene transcription with respect to the acute actions of this drug. This …
tolerance in adiponectin gene transcription with respect to the acute actions of this drug. This …
Nitric oxide is critical for avoiding hepatic lipid overloading via IL-6 induction during liver regeneration after partial hepatectomy in mice
Y Yu, M Tamai, Y Tagawa - Experimental animals, 2017 - jstage.jst.go.jp
Nitric oxide (NO), generated from L-arginine by three different isoforms of nitric oxide
synthase (NOS), is a pleiotropic factor to regulate physiological functions in almost every …
synthase (NOS), is a pleiotropic factor to regulate physiological functions in almost every …
IL-6 上调SCD1 表达对HepG2 细胞脂质合成功能的影响
曹白鸽， 刘冲霄， 陈源文， 董艳 - 实用肝脏病杂志, 2019 - manu43.magtech.com.cn
目的探讨IL-6 对HepG2 细胞硬脂酰辅酶A 去饱和酶1 (SCD1) 基因的影响及其SCD1
基因表达的改变对细胞脂质合成的影响. 方法应用rIL-6 刺激HepG2 细胞, 检测细胞内脂质合成 …
基因表达的改变对细胞脂质合成的影响. 方法应用rIL-6 刺激HepG2 细胞, 检测细胞内脂质合成 …