Structural mechanism of mitochondrial membrane remodelling by human OPA1
A von der Malsburg, GM Sapp, KE Zuccaro… - Nature, 2023 - nature.com
Distinct morphologies of the mitochondrial network support divergent metabolic and
regulatory processes that determine cell function and fate,–. The mechanochemical GTPase …
regulatory processes that determine cell function and fate,–. The mechanochemical GTPase …
DNA Sequence Control of Enzyme Filamentation and Activation of the SgrAI Endonuclease
N Ghadirian, RD Morgan, NC Horton - Biochemistry, 2024 - ACS Publications
Enzyme polymerization (also known as filamentation) has emerged as a new layer of
enzyme regulation. SgrAI is a sequence-dependent DNA endonuclease that forms …
enzyme regulation. SgrAI is a sequence-dependent DNA endonuclease that forms …
[HTML][HTML] Identification and analysis of mitochondria-related central genes in steroid-induced osteonecrosis of the femoral head, along with drug prediction
Z Ma, J Sun, Q Jiang, Y Zhao, H Jiang, P Sun… - Frontiers in …, 2024 - frontiersin.org
Purpose Steroid-induced osteonecrosis of the femoral head (SONFH) is a refractory
orthopedic hip joint disease that primarily affects middle-aged and young individuals …
orthopedic hip joint disease that primarily affects middle-aged and young individuals …
[HTML][HTML] Cardiolipin clustering promotes mitochondrial membrane dynamics
Cardiolipin (CL) is a mitochondria-specific phospholipid that forms heterotypic interactions
with membrane-shaping proteins and regulates the dynamic remodeling and function of …
with membrane-shaping proteins and regulates the dynamic remodeling and function of …
Filament formation drives catalysis by glutaminase enzymes important in cancer progression
The glutaminase enzymes GAC and GLS2 catalyze the hydrolysis of glutamine to glutamate,
satisfying the 'glutamine addiction'of cancer cells. They are the targets of anti-cancer drugs; …
satisfying the 'glutamine addiction'of cancer cells. They are the targets of anti-cancer drugs; …
LACTB exerts tumor suppressor properties in epithelial ovarian cancer through regulation of Slug
V Cutano, JMF Mendes… - Life Science …, 2023 - life-science-alliance.org
Epithelial–mesenchymal transition (EMT) is a cellular mechanism used by cancer cells to
acquire migratory and stemness properties. In this study, we show, through in vitro, in vivo …
acquire migratory and stemness properties. In this study, we show, through in vitro, in vivo …
Proteolytic Regulation of Mitochondrial Architecture
G Purohit, O Khalimonchuk - The Dynamic Nature of Mitochondria - taylorfrancis.com
The multifaceted biological roles of mitochondria are central to both normal cellular
physiology and a gamut of human disorders. One distinctive feature of these organelles is …
physiology and a gamut of human disorders. One distinctive feature of these organelles is …