Structural mechanism of mitochondrial membrane remodelling by human OPA1

A von der Malsburg, GM Sapp, KE Zuccaro… - Nature, 2023 - nature.com
Distinct morphologies of the mitochondrial network support divergent metabolic and
regulatory processes that determine cell function and fate,–. The mechanochemical GTPase …

DNA Sequence Control of Enzyme Filamentation and Activation of the SgrAI Endonuclease

N Ghadirian, RD Morgan, NC Horton - Biochemistry, 2024 - ACS Publications
Enzyme polymerization (also known as filamentation) has emerged as a new layer of
enzyme regulation. SgrAI is a sequence-dependent DNA endonuclease that forms …

[HTML][HTML] Identification and analysis of mitochondria-related central genes in steroid-induced osteonecrosis of the femoral head, along with drug prediction

Z Ma, J Sun, Q Jiang, Y Zhao, H Jiang, P Sun… - Frontiers in …, 2024 - frontiersin.org
Purpose Steroid-induced osteonecrosis of the femoral head (SONFH) is a refractory
orthopedic hip joint disease that primarily affects middle-aged and young individuals …

[HTML][HTML] Cardiolipin clustering promotes mitochondrial membrane dynamics

KE Zuccaro, LA Abriata, FTP Meireles, FR Moss III… - …, 2024 - pmc.ncbi.nlm.nih.gov
Cardiolipin (CL) is a mitochondria-specific phospholipid that forms heterotypic interactions
with membrane-shaping proteins and regulates the dynamic remodeling and function of …

Filament formation drives catalysis by glutaminase enzymes important in cancer progression

S Feng, C Aplin, TTT Nguyen, SK Milano… - Nature …, 2024 - nature.com
The glutaminase enzymes GAC and GLS2 catalyze the hydrolysis of glutamine to glutamate,
satisfying the 'glutamine addiction'of cancer cells. They are the targets of anti-cancer drugs; …

LACTB exerts tumor suppressor properties in epithelial ovarian cancer through regulation of Slug

V Cutano, JMF Mendes… - Life Science …, 2023 - life-science-alliance.org
Epithelial–mesenchymal transition (EMT) is a cellular mechanism used by cancer cells to
acquire migratory and stemness properties. In this study, we show, through in vitro, in vivo …

Proteolytic Regulation of Mitochondrial Architecture

G Purohit, O Khalimonchuk - The Dynamic Nature of Mitochondria - taylorfrancis.com
The multifaceted biological roles of mitochondria are central to both normal cellular
physiology and a gamut of human disorders. One distinctive feature of these organelles is …