[HTML][HTML] State-of-the-art dermatophyte infections: epidemiology aspects, pathophysiology, and resistance mechanisms

NM Martinez-Rossi, NTA Peres, TA Bitencourt… - Journal of Fungi, 2021 - mdpi.com
The burden of fungal infections is not widely appreciated. Although these infections are
responsible for over one million deaths annually, it is estimated that one billion people are …

[HTML][HTML] Epidemiology and diagnostic perspectives of dermatophytoses

MF Petrucelli, MH Abreu, BAM Cantelli, GG Segura… - Journal of Fungi, 2020 - mdpi.com
Dermatophytoses affect about 25% of the world population, and the filamentous fungus
Trichophyton rubrum is the main causative agent of this group of diseases. Dermatomycoses …

Keratin hydrolysis by dermatophytes

DK Mercer, CS Stewart - Medical mycology, 2019 - academic.oup.com
Dermatophytes are the most common cause of superficial fungal infections (tinea infections)
and are a specialized group of filamentous fungi capable of infecting and degrading …

[HTML][HTML] Metabolomic analysis of Trichophyton rubrum and Microsporum canis during keratin degradation

A Ciesielska, A Kawa, K Kanarek, A Soboń… - Scientific reports, 2021 - nature.com
Keratin is important and needed for the growth of dermatophytes in the host tissue. In turn,
the ability to invade keratinised tissues is defined as a pivotal virulence attribute of this group …

[HTML][HTML] Transcriptome-wide survey of gene expression changes and alternative splicing in Trichophyton rubrum in response to undecanoic acid

NS Mendes, TA Bitencourt, PR Sanches… - Scientific reports, 2018 - nature.com
While fatty acids are known to be toxic to dermatophytes, key physiological aspects of the
Trichophyton rubrum response to undecanoic acid (UDA), a medium chain saturated fatty …

[HTML][HTML] Chalcones repressed the AURKA and MDR proteins involved in metastasis and multiple drug resistance in breast cancer cell lines

TT Komoto, TM Bernardes, TB Mesquita, LFB Bortolotto… - Molecules, 2018 - mdpi.com
In the present investigation, trans-chalcone and licochalcone A were tested against MCF-7
and BT-20 breast cancer cell lines for anti-tumor activity. We found that both chalcones down …

[HTML][HTML] Dermatophyte infection: from fungal pathogenicity to host immune responses

R Deng, X Wang, R Li - Frontiers in Immunology, 2023 - frontiersin.org
Dermatophytosis is a common superficial infection caused by dermatophytes, a group of
pathogenic keratinophilic fungi. Apart from invasion against skin barrier, host immune …

[HTML][HTML] Dual RNA-Seq Analysis of Trichophyton rubrum and HaCat Keratinocyte Co-Culture Highlights Important Genes for Fungal-Host Interaction

MF Petrucelli, K Peronni, PR Sanches, TT Komoto… - Genes, 2018 - mdpi.com
The dermatophyte Trichophyton rubrum is the major fungal pathogen of skin, hair, and nails
that uses keratinized substrates as the primary nutrients during infection. Few strategies are …

Caffeic acid and licochalcone A interfere with the glyoxylate cycle of Trichophyton rubrum

BAM Cantelli, TA Bitencourt, TT Komoto… - Biomedicine & …, 2017 - Elsevier
Trichophyton rubrum is the most common causative agent of dermatomycoses worldwide.
Despite the increasing incidence of fungal infections, the number of commercially available …

[HTML][HTML] Exploring the Therapeutic Potential of trans-Chalcone: Modulation of MicroRNAs Linked to Breast Cancer Progression in MCF-7 Cells

TT Komoto, FG Nishimura, AF Evangelista… - International Journal of …, 2023 - mdpi.com
Breast cancer is responsible for 25% of all cancers that affect women. Due to its high
heterogeneity pattern in clinical diagnosis and its molecular profile differences, researchers …