The practice of polypharmacology is not a new concept but the approaches which are being
adopted for administering the two or more drugs together are varied from time to time …

Compounds incorporating guanidine moieties constitute a versatile class of biologically
interesting molecules with a wide array of applications. As such, guanidines have been …

The urea functionality is inherent to numerous bioactive compounds, including a variety of
clinically approved therapies. Urea containing compounds are increasingly used in …

This digest covers some of the most relevant progress in malaria drug discovery published
between 2010 and 2012. There is an urgent need to develop new antimalarial drugs. Such …

The epigenome of the malaria parasite, Plasmodium falciparum, is associated with
regulation of various essential processes in the parasite including control of proliferation …

The continued emergence of resistance to front-line antimalarial treatments is of great
concern. Therefore, new compounds that potentially have a novel target in various …

Antibiotic resistance is a growing threat to human health exacerbated by a lack of new
antibiotics. We now describe a series of substituted diamines that produce rapid bactericidal …

In this study, we aimed to synthesize, characterize, and investigate the efficacy of silver
nanoparticles (AgNPs) derived from the fruit and leaf extracts of C. ambigua against free …

A novel series of antimalarial benzimidazole derivatives incorporating phenolic Mannich
base side chains at the C2 position, which possess dual asexual blood and sexual stage …

SQ109 is a tuberculosis drug candidate that has high potency against Mycobacterium
tuberculosis and is thought to function at least in part by blocking cell wall biosynthesis by …