The endoplasmic reticulum (ER) functions as a quality-control organelle for protein
homeostasis, or “proteostasis”. The protein quality control systems involve ER-associated …

Programmed cell death has a vital role in embryonic development and tissue homeostasis.
Necroptosis is an alternative mode of regulated cell death mimicking features of apoptosis …

Inherited mutations in the rod visual pigment, rhodopsin, cause the degenerative blinding
condition, retinitis pigmentosa (RP). Over 150 different mutations in rhodopsin have been …

Inflammation underpins and contributes to the pathogenesis of many retinal degenerative
diseases. The recruitment and activation of both resident microglia and recruited …

The discovery of the necroptosis, a form of regulated necrosis that is mediated by receptor-
interacting protein kinase 1 (RIPK1), RIPK3, and mixed-lineage kinase domain-like …

RIPK1 is a master regulator of inflammatory signaling and cell death and increased RIPK1
activity is observed in human diseases, including Alzheimer's disease (AD) and amyotrophic …

Innate immune cells such as neutrophils, monocyte-macrophages and microglial cells are
pivotal for the health and disease of the retina. For the maintenance of retinal homeostasis …

Inherited retinal dystrophies (IRDs) are a large group of genetically and clinically
heterogeneous diseases characterized by the progressive degeneration of the retina …

Inherited retinal dystrophies (IRDs) are a group of retinal disorders that cause progressive
and severe loss of vision because of retinal cell death, mainly photoreceptor cells. IRDs …

Diabetic retinopathy (DR) is the leading cause of visual impairment and acquired blindness
among adults worldwide. Retinal microvascular pericyte deficiency is one of the earliest …