Natural killer (NK) cells constitute our bodies' frontline defense system, guarding against
tumors and launching attacks against infections. The activities of NK cells are regulated by …

Autoimmune diseases generally result from the loss of self-tolerance (ie, failure of the
immune system to distinguish self from non-self), and are characterized by autoantibody …

The development of type 1 diabetes involves a complex interaction between pancreatic β-
cells and cells of both the innate and adaptive immune systems. Analyses of the interactions …

Natural killer (NK) cells can be swiftly mobilized by danger signals and are among the
earliest arrivals at target organs of disease. However, the role of NK cells in mounting …

Rapamycin/interleukin-2 (IL-2) combination treatment of NOD mice effectively treats
autoimmune diabetes. We performed a phase 1 clinical trial to test the safety and …

The development of pancreatic cancer requires recruitment and activation of different
macrophage populations. However, little is known about how macrophages are attracted to …

The pathogenesis of autoimmunity remains to be fully elucidated, although the contribution
of genetic and environmental factors is generally recognized. Despite autoimmune …

Natural killer (NK) cells are innate lymphocytes that play a critical role in early host defense
against viruses. Through their cytolytic capacity and generation of cytokines and …

Human T2D is characterized by a low-grade systemic inflammation, loss of β-cells, and
diminished insulin production. Local islet immunity is still poorly understood, and hence, we …

Natural killer (NK) cells are a specialised population of innate lymphoid cells (ILCs) that help
control local immune responses. Through natural cytotoxicity, production of cytokines and …