Since its discovery as a primary component in cytoplasmic aggregates in post-mortem tissue
of patients with Amyotrophic Lateral Sclerosis (ALS), TAR DNA Binding Protein 43 kDa (TDP …

Amyotrophic Lateral Sclerosis | New England Journal of Medicine Skip to main content The
New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …

Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease that
is characterized by motor neuron loss and that leads to paralysis and death 2–5 years after …

Human induced pluripotent stem cells (iPSC) hold promise for modeling diseases in
individual human genetic backgrounds and thus for developing precision medicine. Here …

Amyotrophic lateral sclerosis (ALS) is a fatal, multigenic, multifactorial, and non-cell
autonomous neurodegenerative disease characterized by upper and lower motor neuron …

In autophagy long‐lived proteins, protein aggregates or damaged organelles are engulfed
by vesicles called autophagosomes prior to lysosomal degradation. Autophagy dysfunction …

At present, there are very few therapeutic options for patients affected by amyotrophic lateral
sclerosis (ALS) and frontotemporal dementia (FTD). However, almost all patients affected by …

Amyotrophic lateral sclerosis (ALS) is characterized by motor neuron degeneration
accompanied by aberrant accumulation and loss of function of the RNA-binding protein …

Abstract Amyotrophic Lateral Sclerosis (ALS) is the most frequent motor neuron disease in
adults. Classical ALS is characterized by the death of upper and lower motor neurons …

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are
neurodegenerative disorders that exist on a disease spectrum due to pathological, clinical …