Entry of oximes into the brain: a review
DE Lorke, H Kalasz, GA Petroianu… - Current medicinal …, 2008 - ingentaconnect.com
The passage of hydrophilic drugs, such as oxime acetylcholinesterase reactivators, into the
central nervous system is restricted by the blood-brain and the blood-cerebrospinal fluid …
central nervous system is restricted by the blood-brain and the blood-cerebrospinal fluid …
Design, evaluation and structure—Activity relationship studies of the AChE reactivators against organophosphorus pesticides
Organophosphate pesticides (OPPs; eg chlorpyrifos, diazinon, paraoxon) are a wide and
heterogeneous group of organophosphorus compounds. Their biological activity of …
heterogeneous group of organophosphorus compounds. Their biological activity of …
Acetylcholinesterase inhibitors: pharmacology and toxicology
MB Colovic, DZ Krstic… - Current …, 2013 - ingentaconnect.com
Acetylcholinesterase is involved in the termination of impulse transmission by rapid
hydrolysis of the neurotransmitter acetylcholine in numerous cholinergic pathways in the …
hydrolysis of the neurotransmitter acetylcholine in numerous cholinergic pathways in the …
A newly developed oxime K203 is the most effective reactivator of tabun-inhibited acetylcholinesterase
Background Based on in vitro and in vivo rat experiments, the newly developed
acetylcholinesterase (AChE) reactivator, K203, appears to be much more effective in the …
acetylcholinesterase (AChE) reactivator, K203, appears to be much more effective in the …
Structure-activity relationship and efficacy of pyridinium oximes in the treatment of poisoning with organophosphorus compounds: a review of recent data
M Jokanovic - Current Topics in Medicinal Chemistry, 2012 - ingentaconnect.com
During more than five decades, pyridinium oximes have been developed as therapeutic
agents used in the medical treatment of poisoning with organophosphorus compounds …
agents used in the medical treatment of poisoning with organophosphorus compounds …
An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun …
The potency of newly developed monoxime bispyridinium compounds (K156, K203) in
reactivating tabun-inhibited acetylcholinesterase and reducing tabun-induced lethal toxic …
reactivating tabun-inhibited acetylcholinesterase and reducing tabun-induced lethal toxic …
Layer-by-layer assembled carbon nanotube-acetylcholinesterase/biopolymer renewable interfaces: SPR and electrochemical characterization
Developing simple, reliable, and cost-effective methods of renewing an inhibited biocatalyst
(eg, enzymatic interfaces) on biosensors is needed to advance multiuse, reusable sensor …
(eg, enzymatic interfaces) on biosensors is needed to advance multiuse, reusable sensor …
In vitro oxime-assisted reactivation of paraoxon-inhibited human acetylcholinesterase and butyrylcholinesterase
L Musilova, K Kuca, YS Jung, D Jun - Clinical Toxicology, 2009 - Taylor & Francis
Introduction. Organophosphorus pesticides and nerve agents are highly toxic to humans
and other living organisms, primarily because of their interaction with enzyme …
and other living organisms, primarily because of their interaction with enzyme …
Therapeutic and reactivating efficacy of oximes K027 and K203 against a direct acetylcholinesterase inhibitor
As oxime-based structures are the only causal antidotes to organophosphate (OP)-inhibited
acetylcholinesterase (AChE), the majority of studies on these have been directed towards …
acetylcholinesterase (AChE), the majority of studies on these have been directed towards …
In vitro oxime protection of human red blood cell acetylcholinesterase inhibited by diisopropyl‐fluorophosphate
Oximes are enzyme reactivators used in treating poisoning with organophosphorus
cholinesterase (AChE) inhibitors. The oxime dose which can be safely administered is …
cholinesterase (AChE) inhibitors. The oxime dose which can be safely administered is …