Tenascin-C (TNC) is highly expressed in cancer tissues. Its cellular sources are cancer and
stromal cells, including fibroblasts/myofibroblasts, and also vascular cells. TNC expressed in …

Colorectal cancer (CRC) remains one of the most common cancers worldwide. Metastatic
disease is ultimately fatal when incurable. Cancer research has evolved to take the …

Tumor cells of colorectal cancer (CRC) release exosomes into the circulation. These
exosomes can mediate communication between cells and affect various tumor‐related …

TMPRSS4 is a novel type II transmembrane serine protease that is highly expressed on the
cell surface in pancreatic, thyroid and other cancer tissues, although its oncogenic …

Deposition of the extracellular matrix protein tenascin-C is part of the reactive stroma
response, which has a critical role in prostate cancer progression. Here, we report that …

Abstract Purpose The dendritic cells (DCs) are key players in the initiation and regulation of
immune responses including antitumor immunity. In the current study, we aimed to elucidate …

Background Long-term cigarette smoking increases the risk of colorectal cancer mortality.
Tobacco's addictive toxin, nicotine, was reported to increase DNA synthesis of colon cancer …

Aim In the current study, we investigated the expression of TGF-β1, its receptor TGFβRII, and
the signaling proteins Smad4 and Smad7 in colorectal cancer tissue in relation to infiltration …

Integrins are heterodimeric transmembrane receptors regulating cell-cell and cell-
extracellular matrix interactions. Of the 24 integrin heterodimers identified in humans, α9β1 …

Growth and survival of tumors at a site of metastasis involve interactions with stromal cells in
the surrounding environment. Stromal cells aid tumor cell growth by producing cytokines as …