Hepatitis B virus (HBV) contributes to hepatocellular carcinoma (HCC) development through
direct and indirect mechanisms. HBV DNA integration into the host genome occurs at early …

The emergence and takeover of hepatitis B virus (HBV) variants carrying mutation (s) in the
preS/S genomic region is a fairly frequent event that may occur spontaneously or may be the …

Viruses must create a suitable cell environment and elude defense mechanisms, which
likely involves interactions with host proteins and subsequent interference with or usurpation …

Hepatocellular carcinoma (HCC) is the third cancer killer worldwide with> 600,000 deaths
every year. Although the major risk factors are known, therapeutic options in patients remain …

Abstract c-Jun activation domain-binding protein-1 (Jab1) acts as a modulator of intracellular
signaling and affects cellular proliferation and apoptosis, through its existence as a …

The discovery of “ground glass” hepatocytes (GGH) that contain hepatitis B virus (HBV)
surface antigens by Hadziyannis and Popper in 1973 represents a historical landmark in the …

Hepatitis B virus (HBV) infection is the main risk factor for hepatocellular carcinoma (HCC)
development, as suggested by many epidemiological and molecular studies (1–13) and as …

Hepatitis B virus (HBV) produces circular RNA (circRNA), whose functions have not yet been
clearly elucidated. In this study, a novel circRNA HBV_circ_1 produced by HBV was …

Oxidative stress is becoming recognized as a key factor in the progression of chronic liver
disease (CLD) and hepatocarcinogenesis. The metabolically important liver is a major …

Hepatocellular carcinoma (HCC) is a hypervascular tumor, and accumulating evidence has
indicated that stimulation of angiogenesis by hepatitis B virus (HBV) may contribute to HCC …