Simple and complex carbohydrates (glycans) have long been known to play major
metabolic, structural and physical roles in biological systems. Targeted microbial binding to …

Chronic inflammation is the main feature of many long-term inflammatory diseases such as
autoimmune diseases, metabolic disorders, and cancer. There is a growing number of …

Cells derived from pluripotent sources in vitro must resemble those found in vivo as closely
as possible at both transcriptional and functional levels in order to be a useful tool for …

How disseminated tumour cells engage specific stromal components in distant organs for
survival and outgrowth is a critical but poorly understood step of the metastatic cascade …

The microenvironment, or niche, surrounding a stem cell largely governs its cellular fate.
Two anatomical niches for hematopoietic stem cells (HSCs) have been reported in the bone …

Cancer metastasis is facilitated by cell–cell interactions between cancer cells and
endothelial cells in distant tissues. In addition, cancer cell interactions with platelets and …

CD44 is a multistructural and multifunctional cell surface molecule involved in cell
proliferation, cell differentiation, cell migration, angiogenesis, presentation of cytokines …

The capacity to direct migration ('homing') of blood-borne cells to a predetermined anatomic
compartment is vital to stem cell–based tissue engineering and other adoptive cellular …

To explore the initial steps by which transplanted mesenchymal stem cells (MSCs) interact
with the vessel wall in the course of extravasation, we studied binding of human MSCs to …

Stem cells reside in a specialized niche that regulates their abundance and fate.
Components of the niche have generally been defined in terms of cells and signaling …