R loops are nucleic acid structures composed of an RNA–DNA hybrid and a displaced
single-stranded DNA. Recently, evidence has emerged that R loops occur more often in the …

Complex mechanisms are in place to maintain genome stability. Ubiquitination of chromatin
plays a central role in these mechanisms. The ever-growing complexity of the ubiquitin (Ub) …

RNA: DNA hybrid structures known as R loops were thought to be rare byproducts of
transcription. In the last decade, however, accumulating evidence has pointed to a new view …

Aberrant R-loop structures are increasingly being realized as an important contributor to
human disease. R loops, which are mainly co-transcriptional, abundant RNA/DNA hybrids …

DNA: RNA hybrid formation is emerging as a significant cause of genome instability in
biological systems ranging from bacteria to mammals. Here we describe the genome-wide …

Since its discovery forty years ago, protein ubiquitination has been an ever-expanding field.
Virtually all biological processes are controlled by the post-translational conjugation of …

R-loops are cellular structures composed of an RNA/DNA hybrid, which is formed when the
RNA hybridises to a complementary DNA strand and a displaced single-stranded DNA. R …

Embryonic stem cells (ESCs) maintain high genomic plasticity, which is essential for their
capacity to enter diverse differentiation pathways. Posttranscriptional modifications of …

Factors linking inflammation and cancer are of great interest. We now report that the
chromatin-targeting E3 ubiquitin ligase RNF20/RNF40, driving histone H2B …

R-loops, which consist of a DNA/RNA hybrid and a displaced single-stranded DNA (ssDNA),
are increasingly recognized as critical regulators of chromatin biology. R-loops are …