R loops: new modulators of genome dynamics and function
JM Santos-Pereira, A Aguilera - Nature Reviews Genetics, 2015 - nature.com
R loops are nucleic acid structures composed of an RNA–DNA hybrid and a displaced
single-stranded DNA. Recently, evidence has emerged that R loops occur more often in the …
single-stranded DNA. Recently, evidence has emerged that R loops occur more often in the …
[HTML][HTML] Histone ubiquitination: an integrative signaling platform in genome stability
F Mattiroli, L Penengo - Trends in Genetics, 2021 - cell.com
Complex mechanisms are in place to maintain genome stability. Ubiquitination of chromatin
plays a central role in these mechanisms. The ever-growing complexity of the ubiquitin (Ub) …
plays a central role in these mechanisms. The ever-growing complexity of the ubiquitin (Ub) …
[PDF][PDF] R loops: from transcription byproducts to threats to genome stability
A Aguilera, T García-Muse - Molecular cell, 2012 - cell.com
RNA: DNA hybrid structures known as R loops were thought to be rare byproducts of
transcription. In the last decade, however, accumulating evidence has pointed to a new view …
transcription. In the last decade, however, accumulating evidence has pointed to a new view …
R loops and links to human disease
P Richard, JL Manley - Journal of molecular biology, 2017 - Elsevier
Aberrant R-loop structures are increasingly being realized as an important contributor to
human disease. R loops, which are mainly co-transcriptional, abundant RNA/DNA hybrids …
human disease. R loops, which are mainly co-transcriptional, abundant RNA/DNA hybrids …
[HTML][HTML] Genome-wide profiling of yeast DNA: RNA hybrid prone sites with DRIP-chip
DNA: RNA hybrid formation is emerging as a significant cause of genome instability in
biological systems ranging from bacteria to mammals. Here we describe the genome-wide …
biological systems ranging from bacteria to mammals. Here we describe the genome-wide …
Dissenting degradation: Deubiquitinases in cell cycle and cancer
T Bonacci, MJ Emanuele - Seminars in cancer biology, 2020 - Elsevier
Since its discovery forty years ago, protein ubiquitination has been an ever-expanding field.
Virtually all biological processes are controlled by the post-translational conjugation of …
Virtually all biological processes are controlled by the post-translational conjugation of …
[HTML][HTML] Out of balance: R-loops in human disease
M Groh, N Gromak - PLoS genetics, 2014 - journals.plos.org
R-loops are cellular structures composed of an RNA/DNA hybrid, which is formed when the
RNA hybridises to a complementary DNA strand and a displaced single-stranded DNA. R …
RNA hybridises to a complementary DNA strand and a displaced single-stranded DNA. R …
[PDF][PDF] RNF20 and USP44 regulate stem cell differentiation by modulating H2B monoubiquitylation
Embryonic stem cells (ESCs) maintain high genomic plasticity, which is essential for their
capacity to enter diverse differentiation pathways. Posttranscriptional modifications of …
capacity to enter diverse differentiation pathways. Posttranscriptional modifications of …
[PDF][PDF] RNF20 links histone H2B ubiquitylation with inflammation and inflammation-associated cancer
Factors linking inflammation and cancer are of great interest. We now report that the
chromatin-targeting E3 ubiquitin ligase RNF20/RNF40, driving histone H2B …
chromatin-targeting E3 ubiquitin ligase RNF20/RNF40, driving histone H2B …
TDRD3 promotes DHX9 chromatin recruitment and R-loop resolution
R-loops, which consist of a DNA/RNA hybrid and a displaced single-stranded DNA (ssDNA),
are increasingly recognized as critical regulators of chromatin biology. R-loops are …
are increasingly recognized as critical regulators of chromatin biology. R-loops are …