[HTML][HTML] Antivirals for COVID-19: a critical review
No specific drugs have been approved for coronavirus disease 2019 (COVID-19) to date as
the development of antivirals usually requires time. Therefore, assessment and use of …
the development of antivirals usually requires time. Therefore, assessment and use of …
A single-cell RNA expression map of human coronavirus entry factors
To predict the tropism of human coronaviruses, we profile 28 SARS-CoV-2 and coronavirus-
associated receptors and factors (SCARFs) using single-cell transcriptomics across various …
associated receptors and factors (SCARFs) using single-cell transcriptomics across various …
SARS‐CoV‐2–host proteome interactions for antiviral drug discovery
X Liu, S Huuskonen, T Laitinen, T Redchuk… - Molecular Systems …, 2021 - embopress.org
Abstract Treatment options for COVID‐19, caused by SARS‐CoV‐2, remain limited.
Understanding viral pathogenesis at the molecular level is critical to develop effective …
Understanding viral pathogenesis at the molecular level is critical to develop effective …
Mechanism of type IA topoisomerases
Topoisomerases in the type IA subfamily can catalyze change in topology for both DNA and
RNA substrates. A type IA topoisomerase may have been present in a last universal …
RNA substrates. A type IA topoisomerase may have been present in a last universal …
Identification and characterization of topoisomerase III beta poisons
We designed and carried out a high-throughput screen for compounds that trap
topoisomerase III beta (TOP3B poisons) by developing a Comparative Cellular Cytotoxicity …
topoisomerase III beta (TOP3B poisons) by developing a Comparative Cellular Cytotoxicity …
Insights into the DNA and RNA Interactions of Human Topoisomerase III Beta Using Molecular Dynamics Simulations
Y Mamun, YC Tse-Dinh… - Journal of Chemical …, 2024 - ACS Publications
Human topoisomerase III beta (hTOP3B) is the only topoisomerase in the human cell that
can act on both DNA and RNA substrates. Recent findings have emphasized the …
can act on both DNA and RNA substrates. Recent findings have emphasized the …
Unravelling the mechanisms of Type 1A topoisomerases using single-molecule approaches
D Spakman, JAM Bakx, AS Biebricher… - Nucleic acids …, 2021 - academic.oup.com
Topoisomerases are essential enzymes that regulate DNA topology. Type 1A family
topoisomerases are found in nearly all living organisms and are unique in that they require …
topoisomerases are found in nearly all living organisms and are unique in that they require …
A dual-activity topoisomerase complex regulates mRNA translation and turnover
S Su, Y Xue, A Sharov, Y Zhang, SK Lee… - Nucleic Acids …, 2022 - academic.oup.com
Abstract Topoisomerase 3β (TOP3B) and TDRD3 form a dual-activity topoisomerase
complex that interacts with FMRP and can change the topology of both DNA and RNA. Here …
complex that interacts with FMRP and can change the topology of both DNA and RNA. Here …
Identification of receptors and factors associated with human coronaviruses in the oral cavity using single-cell RNA sequencing
F Gao, W Lin, X Wang, M Liao, M Zhang, N Qin, X Chen… - Heliyon, 2024 - cell.com
Abstract Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) ravaged the
world, and Coronavirus Disease 2019 (COVID-19) exhibited highly prevalent oral symptoms …
world, and Coronavirus Disease 2019 (COVID-19) exhibited highly prevalent oral symptoms …
A dual-activity topoisomerase complex promotes both transcriptional activation and repression in response to starvation
S Su, Y Xue, SK Lee, Y Zhang, J Fan, S De… - Nucleic Acids …, 2023 - academic.oup.com
Topoisomerases are required to release topological stress generated by RNA polymerase II
(RNAPII) during transcription. Here, we show that in response to starvation, the complex of …
(RNAPII) during transcription. Here, we show that in response to starvation, the complex of …