Background: Platelet-rich plasma (PRP) and hyaluronic acid (HA) are 2 nonoperative
treatment options for knee osteoarthritis (OA) that are supposed to provide symptomatic …

Although platelets are widely recognized as having a critical role in primary hemostasis and
thrombosis, increasing experimental and clinical evidence identifies these enucleated cells …

Articular hyaline cartilage is extensively hydrated, but it is neither innervated nor
vascularized, and its low cell density allows only extremely limited self-renewal. Most clinical …

Background: Platelet-rich plasma (PRP) injections have been proposed as a new
conservative option for knee degeneration to provide symptomatic relief and delay surgical …

Abstract Purpose of Review This review evaluates current clinical literature on the use of
platelet-rich plasma (PRP), including leukocyte-rich PRP (LR-PRP) and leukocyte-poor PRP …

Objective To evaluate effectiveness, in terms of patient-reported outcome measures, of
platelet-rich plasma (PRP) injections for knee osteoarthritis compared to placebo and other …

Background Quite a few randomized controlled trials (RCTs) investigating the efficacy of
platelet-rich plasma (PRP) for treatment of knee osteoarthritis (OA) have been recently …

Introduction Regarding the efficacy of intra-articular injections of platelet-rich plasma,
hyaluronic acid and corticosteroids, current evidence is controversial. The superiority of one …

Abstract Purpose of Review Knee and hip osteoarthritis (OA) are major public health
problems worldwide causing pain, disability and impaired quality of life. This narrative paper …

Background Knee osteoarthritis (KOA) is a degenerative joint disease leading to pain and
disability for which no curative treatment exists. Intra-articular (IA) therapies are part of this …