CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond
Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse physiological
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …
Migraine: disease characterisation, biomarkers, and precision medicine
M Ashina, GM Terwindt, MAM Al-Karagholi, I De Boer… - The Lancet, 2021 - thelancet.com
Migraine is a disabling neurological disorder, diagnosis of which is based on clinical criteria.
A shortcoming of these criteria is that they do not fully capture the heterogeneity of migraine …
A shortcoming of these criteria is that they do not fully capture the heterogeneity of migraine …
Shared and independent roles of CGRP and PACAP in migraine pathophysiology
A Kuburas, AF Russo - The Journal of Headache and Pain, 2023 - Springer
The neuropeptides calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-
activating polypeptide (PACAP) have emerged as mediators of migraine pathogenesis. Both …
activating polypeptide (PACAP) have emerged as mediators of migraine pathogenesis. Both …
Salivary CGRP and erenumab treatment response: towards precision medicine in migraine
A Alpuente, VJ Gallardo, L Asskour… - Annals of …, 2022 - Wiley Online Library
Objective We aimed (1) to analyze salivary calcitonin gene‐related peptide (CGRP) levels in
patients with migraine,(2) to predict erenumab response from baseline CGRP levels, and (3) …
patients with migraine,(2) to predict erenumab response from baseline CGRP levels, and (3) …
From transformation to chronification of migraine: pathophysiological and clinical aspects
M Torres-Ferrús, F Ursitti, A Alpuente… - The journal of headache …, 2020 - Springer
Chronic migraine is a neurological disorder characterized by 15 or more headache days per
month of which at least 8 days show typical migraine features. The process that describes …
month of which at least 8 days show typical migraine features. The process that describes …
Dual therapy with anti‐CGRP monoclonal antibodies and botulinum toxin for migraine prevention: is there a rationale?
Objective To narratively review the pathophysiological rationale of dual therapy with anti‐
calcitonin gene‐related peptide monoclonal antibodies and botulinum toxin type A in …
calcitonin gene‐related peptide monoclonal antibodies and botulinum toxin type A in …
Salivary CGRP can monitor the different migraine phases: CGRP (in) dependent attacks
A Alpuente, VJ Gallardo, L Asskour, E Caronna… - …, 2022 - journals.sagepub.com
Background CGRP plays a key role in the transmission and modulation of nociceptive
signals and is a critical component in the pathogenesis of migraine. Objective To assess …
signals and is a critical component in the pathogenesis of migraine. Objective To assess …
Migraine treatment: Towards new pharmacological targets
M Silvestro, LF Iannone, I Orologio, A Tessitore… - International Journal of …, 2023 - mdpi.com
Migraine is a debilitating neurological condition affecting millions of people worldwide. Until
a few years ago, preventive migraine treatments were based on molecules with pleiotropic …
a few years ago, preventive migraine treatments were based on molecules with pleiotropic …
Dural immune cells, CGRP, and migraine
LK Balcziak, AF Russo - Frontiers in neurology, 2022 - frontiersin.org
Migraine is the most common neurological disorder in the world, affecting 12% of the
population. Migraine involves the central nervous system, trigeminal nerves and meninges …
population. Migraine involves the central nervous system, trigeminal nerves and meninges …
Sex hormones and calcitonin gene–related peptide in women with migraine: a cross-sectional, matched cohort study
B Raffaelli, E Storch, LH Overeem, M Terhart… - Neurology, 2023 - AAN Enterprises
Background and Objectives Sex hormones may modulate calcitonin gene-related peptide
(CGRP) release in the trigeminovascular system. We studied CGRP concentrations in …
(CGRP) release in the trigeminovascular system. We studied CGRP concentrations in …