Rho GTPase signaling in cancer progression and dissemination

E Crosas-Molist, R Samain… - Physiological …, 2022 - journals.physiology.org
Rho GTPases are a family of small G proteins that regulate a wide array of cellular
processes related to their key roles controlling the cytoskeleton. Cancer is a multistep …

[HTML][HTML] Stem cell programs in cancer initiation, progression, and therapy resistance

T Huang, X Song, D Xu, D Tiek, A Goenka, B Wu… - Theranostics, 2020 - ncbi.nlm.nih.gov
Over the past few decades, substantial evidence has convincingly revealed the existence of
cancer stem cells (CSCs) as a minor subpopulation in cancers, contributing to an aberrantly …

The multi-factorial nature of clinical multidrug resistance in cancer

YG Assaraf, A Brozovic, AC Gonçalves… - Drug resistance …, 2019 - Elsevier
Curative cancer therapy remains a major challenge particularly in cancers displaying
multidrug resistance (MDR). The MDR phenotype is characterized by cross-resistance to a …

[HTML][HTML] Lipid droplets: platforms with multiple functions in cancer hallmarks

ALS Cruz, EA Barreto, NPB Fazolini, JPB Viola… - Cell death & …, 2020 - nature.com
Lipid droplets (also known as lipid bodies) are lipid-rich, cytoplasmic organelles that play
important roles in cell signaling, lipid metabolism, membrane trafficking, and the production …

Cancer stem cells (CSCs) in drug resistance and their therapeutic implications in cancer treatment

LTH Phi, IN Sari, YG Yang, SH Lee, N Jun… - Stem cells …, 2018 - Wiley Online Library
Cancer stem cells (CSCs), also known as tumor‐initiating cells (TICs), are suggested to be
responsible for drug resistance and cancer relapse due in part to their ability to self‐renew …

[PDF][PDF] Cancer stem cells: the architects of the tumor ecosystem

BC Prager, Q Xie, S Bao, JN Rich - Cell stem cell, 2019 - cell.com
Cancer stem cells (CSCs) proactively remodel their microenvironment to maintain a
supportive niche. Viewed through the lens of an ecosystem, numerous tumor components …

[PDF][PDF] Targeting cancer stemness in the clinic: from hype to hope

C Saygin, D Matei, R Majeti, O Reizes, JD Lathia - Cell stem cell, 2019 - cell.com
Tumors are composed of non-homogeneous cell populations exhibiting varying degrees of
genetic and functional heterogeneity. Cancer stem cells (CSCs) are capable of sustaining …

[HTML][HTML] Modeling neoplastic disease with spheroids and organoids

M Zanoni, M Cortesi, A Zamagni, C Arienti… - Journal of hematology & …, 2020 - Springer
Cancer is a complex disease in which both genetic defects and microenvironmental
components contribute to the development, progression, and metastasization of disease …

Bioactive synthetic polymers

K Jung, N Corrigan, EHH Wong, C Boyer - Advanced Materials, 2022 - Wiley Online Library
Synthetic polymers are omnipresent in society as textiles and packaging materials, in
construction and medicine, among many other important applications. Alternatively, natural …

[HTML][HTML] Status and challenges of plant-anticancer compounds in cancer treatment

P Garcia-Oliveira, P Otero, AG Pereira, F Chamorro… - Pharmaceuticals, 2021 - mdpi.com
Nowadays, cancer is one of the deadliest diseases in the world, which has been estimated
to cause 9.9 million deaths in 2020. Conventional treatments for cancer commonly involve …