The microbiota-gut-brain axis is a bidirectional signaling mechanism between the
gastrointestinal tract and the central nervous system. The complexity of the intestinal …

Depression is a worldwide disease causing severe disability, morbidity, and mortality.
Despite abundant studies, the precise mechanisms underlying the pathophysiology of …

Anhedonia, as evidenced by impaired pleasurable response to reward, reduced reward
motivation, and/or deficits in reward-related learning, is a common feature of depression …

Major depression is a serious psychiatric disorder, occurring in up to 20% of the population.
Despite its devastating burden, the neurobiological changes associated with depression are …

Major depressive disorder is a complex multifactorial condition with a so far poorly
characterized underlying pathophysiology. Consequently, the available treatments are far …

Depression is a common and complex mental and emotional disorder that causes disability,
morbidity, and quite often mortality around the world. Depression is closely related to several …

Spermidine is a naturally occurring endogenous polyamine synthesized from diamine
putrescine. It is a well-known autophagy inducer that maintains cellular and neuronal …

Major Depression is a severe psychiatric condition with a still poorly understood etiology. In
the last years, evidence supporting the neuroinflammatory hypothesis of depression has …

Hundreds of cell types form the vertebrate brain but it is largely unknown how similar cellular
repertoires are between or within species or how cell-type diversity evolves. To examine cell …

Currently, a significant amount of data is accumulated showing that neuroinflammation is
one of the key processes in the development of brain pathology in trauma …