Diabetic nephropathy (DN) is one of the most common complications in diabetes mellitus
and the leading cause of end-stage renal disease. TGF-β is a pleiotropic cytokine and has …

Beta (β) cell dysfunction or loss is the common pathological feature in all types of diabetes
mellitus (diabetes). Resolving the underlying mechanism may facilitate the treatment of …

Diabetic nephropathy (DN) leads to high morbidity and disability. Inflammation plays a
critical role in the pathogenesis of DN, which involves renal cells and immune cells, the …

Transforming growth factor-β (TGF-β)/Smad3 signaling has been shown to play important
roles in fibrotic and inflammatory diseases. However, the role of Smad3 in dyslipidemia and …

Pancreatic β cell expansion and functional maturation during the birth-to-weaning period is
driven by epigenetic programs primarily triggered by growth factors, hormones, and nutrients …

TGF-β/Smad3 signaling plays a critical role in type 2 diabetes (T2D) and type 2 diabetic
nephropathy (T2DN), but treatment by specifically targeting Smad3 remains unexplored. To …

Transforming growth factor-β (TGF-β) is a crucial pathogenic mediator of inflammatory
diseases. In tissue fibrosis, TGF-β regulates the pathogenic activity of infiltrated …

Rationale: Poor β cell proliferation is one of the detrimental factors hindering islet cell
replacement therapy for patients with diabetes. Smad3 is an important transcriptional factor …

Renal fibrosis is a common feature of all types of chronic kidney disease (CKD) and is tightly
regulated by the TGF-β/Smad3 pathway. Let-7i-5p belongs to the let-7 microRNA family with …

Currently, a major challenge in material engineering is to develop a cell-safe biomaterial
with significant utility in processing technology such as 3D bioprinting. The main goal of this …