[HTML][HTML] Control of human toxoplasmosis

NC Smith, C Goulart, JA Hayward, A Kupz… - International journal for …, 2021 - Elsevier
Toxoplasmosis is caused by Toxoplasma gondii, an apicomplexan parasite that is able to
infect any nucleated cell in any warm-blooded animal. Toxoplasma gondii infects around 2 …

Mechanisms of Toxoplasma gondii persistence and latency

WJ Sullivan Jr, V Jeffers - FEMS microbiology reviews, 2012 - academic.oup.com
Toxoplasma gondii is an obligate intracellular protozoan parasite that causes opportunistic
disease, particularly in immunocompromised individuals. Central to its transmission and …

A Plasmodium falciparum histone deacetylase regulates antigenic variation and gametocyte conversion

BI Coleman, KM Skillman, RHY Jiang, LM Childs… - Cell host & …, 2014 - cell.com
The asexual forms of the malaria parasite Plasmodium falciparum are adapted for chronic
persistence in human red blood cells, continuously evading host immunity using …

The molecular biology and immune control of chronic Toxoplasma gondii infection

XY Zhao, SE Ewald - The Journal of clinical investigation, 2020 - Am Soc Clin Investig
Toxoplasma gondii is an incredibly successful parasite owing in part to its ability to persist
within cells for the life of the host. Remarkably, at least 350 host species of T. gondii have …

Animals are key to human toxoplasmosis

D Schlüter, W Däubener, G Schares, U Groß… - International Journal of …, 2014 - Elsevier
Toxoplasma gondii is an extremely sucessfull protozoal parasite which infects almost all
mamalian species including humans. Approximately 30% of the human population …

Coordinated Progression through Two Subtranscriptomes Underlies the Tachyzoite Cycle of Toxoplasma gondii

MS Behnke, JC Wootton, MM Lehmann, JB Radke… - PloS one, 2010 - journals.plos.org
Background Apicomplexan parasites replicate by varied and unusual processes where the
typically eukaryotic expansion of cellular components and chromosome cycle are …

A latent ability to persist: differentiation in Toxoplasma gondii

V Jeffers, Z Tampaki, K Kim, WJ Sullivan - Cellular and Molecular Life …, 2018 - Springer
A critical factor in the transmission and pathogenesis of Toxoplasma gondii is the ability to
convert from an acute disease-causing, proliferative stage (tachyzoite), to a chronic, dormant …

The bradyzoite: a key developmental stage for the persistence and pathogenesis of toxoplasmosis

A Cerutti, N Blanchard, S Besteiro - Pathogens, 2020 - mdpi.com
Toxoplasma gondii is a ubiquitous parasitic protist found in a wide variety of hosts, including
a large proportion of the human population. Beyond an acute phase which is generally self …

A MORC-driven transcriptional switch controls Toxoplasma developmental trajectories and sexual commitment

DC Farhat, C Swale, C Dard, D Cannella, P Ortet… - Nature …, 2020 - nature.com
Toxoplasma gondii has a complex life cycle that is typified by asexual development that
takes place in vertebrates, and sexual reproduction, which occurs exclusively in felids and is …

HDAC inhibitors in parasitic diseases

KT Andrews, A Haque, MK Jones - Immunology and cell …, 2012 - Wiley Online Library
Parasitic diseases cause significant global morbidity and mortality, particularly in
underdeveloped regions of the world. Malaria alone causes∼ 800 000 deaths each year …