As the endpoint for the ubiquitin-proteasome system, the 26S proteasome is the principal
proteolytic machine responsible for regulated protein degradation in eukaryotic cells. The …

The ubiquitin proteasome pathway is responsible for most of the protein degradation in
mammalian cells. Rates of degradation by this pathway have generally been assumed to be …

Proteins are targeted to the proteasome by the attachment of ubiquitin chains, which are
markedly varied in structure. Three proteasome subunits–Rpn10, Rpn13, and Rpn1–can …

The 26S proteasome is the most complex ATP-dependent protease machinery, of~ 2.5 MDa
mass, ubiquitously found in all eukaryotes. It selectively degrades ubiquitin-conjugated …

The 26S proteasome is the principal macromolecular machine responsible for protein
degradation in eukaryotes. However, little is known about the detailed kinetics and …

Intracellular proteins continuously turn over by degradation and synthesis in all organ
tissues. Owing to its irreversible nature, protein degradation is a highly selective process to …

The ubiquitin proteasome system controls the concentrations of regulatory proteins and
removes damaged and misfolded proteins from cells. Proteins are targeted to the protease …

Misfolded proteins in the endoplasmic reticulum (ER) are removed through a process known
as ER-associated degradation (ERAD). ERAD occurs through an integral membrane protein …

The 26S proteasome is responsible for regulated proteolysis in eukaryotic cells. Its
substrates are diverse in structure, function, sequence length, and amino acid composition …

Highlights•Many types of ubiquitin modification can target proteins to the proteasome for
degradation.•The ubiquitin receptors of the RP individually and cooperatively function to …