The main motivation for “hierarchical biomechanics” is that the wide variability of mechanical
properties encountered at the macroscopic scale may be traced back to just a few …

Modelling and simulation in mechanobiology play an increasingly important role to unravel
the complex mechanisms that allow resident cells to sense and respond to mechanical cues …

Atherosclerotic plaque rupture in carotid arteries is a major cause of cerebrovascular events.
Plaque rupture is the mechanical failure of the heterogeneous fibrous plaque tissue. Local …

The micromechanics of composites with multiple phases of different shapes embedded into
a matrix phase, typically requires symmetrization strategies for their homogenized elasticity …

Multiscale mechanical models in biomaterials research have largely relied on simplifying the
microstructure in order to make large-scale simulations tractable. The microscale …

Growth and remodeling in soft tissue changes, in general, the orientation distribution of the
collagen fibers in the tissue. So far, the governing principles are still incompletely …

Present study provides a numerical investigation on multiscale boundary conditions in the
computational homogenization of a representative volume element (RVE) of tendon …

Our aim is to estimate regional mechanical properties of the annulus fibrosus (AF) using a
multi-relaxation tensile test and to examine the relevance of using the transverse dilatations …

Fibrous collagen networks are well known to play a central role in the passive
biomechanical response of soft connective tissues to applied loads. In the current chapter …

Stress and strain average rules are the key conceptual pillars of the wide field of continuum
micromechanics of materials. The aforementioned rules express that the spatial average of …