Many of the fundamental concepts of signal transduction and kinase activity are attributed to
the discovery and crystallization of cAMP-dependent protein kinase, or protein kinase A …

Hedgehog (Hh) signaling and mTOR signaling, essential for embryonic development and
cellular metabolism, are both coordinated by the primary cilium. Observations from cancer …

The primary cilium is a signaling compartment that interprets Hedgehog signals through
changes of its protein, lipid, and second messenger compositions. Here, we combine …

Abstract The Hedgehog (Hh) cascade is central to development, tissue homeostasis and
cancer. A pivotal step in Hh signal transduction is the activation of glioma-associated (GLI) …

The Hedgehog (Hh) pathway is essential for organ development, homeostasis, and
regeneration. Dysfunction of this cascade drives several cancers. To control expression of …

Primary cilia project from the surface of most vertebrate cells and are key in sensing
extracellular signals and locally transducing this information into a cellular response. Recent …

Primary cilia are microtubule-based, non-motile sensory organelles present in most types of
growth-arrested eukaryotic cells. They are transduction hubs that receive and transmit …

G protein-coupled receptors (GPCRs) are a large family of cell surface receptors that are the
targets for many different classes of pharmacotherapy. The islets of Langerhans are central …

Signaling from ciliary microdomains controls developmental processes in metazoans.
Trypanosome transmission requires development and migration in the tsetse vector …

Cardiovascular diseases are important causes of mortality and morbidity worldwide.
Vascular smooth muscle cells (SMCs) are major components of blood vessels and are …