The TP53 tumor suppressor is the most frequently altered gene in human cancers, and has
been a major focus of oncology research. The p53 protein is a transcription factor that can …

Simple Summary Mutations in the tumor suppressor p53 (p53) occur in~ 50% of human
cancers, the majority of which are missense mutations. Mutations in p53 not only impair the …

TP53, which encodes the tumour-suppressor protein p53, is the most frequently mutated
gene across all cancer types. The presence of mutant p53 predisposes to cancer …

Genomic and functional study of existing and emerging sarcoma targets, such as fusion
proteins, chromosomal aberrations, reduced tumor suppressor activity, and oncogenic …

The tumor suppressor p53 (TP53) is the most frequently mutated human gene. Mutations in
TP53 not only disrupt its tumor suppressor function, but also endow oncogenic gain-of …

Simple Summary Treatment of osteosarcoma, apart from chemotherapy modifications, has
not changed for approximately 30 years. Similarly, as in other tumors, mutations in the TP53 …

Missense mutations in the TP53 gene lead to accumulation of dysfunctional TP53 proteins in
tumors, showing oncogenic gain-of-function (GOF) activities. Stabilization of mutant TP53 …

Enhanced proliferation and survival are common features of cancer cells. Cancer cells are
metabolically reprogrammed which aids in their survival in nutrient-poor environments …

Targeted therapies in cancer treatment can improve in vivo efficacy and reduce adverse
effects by altering the tissue exposure of specific biomolecules. However, there are still large …

Accumulation of mutant p53 (mutp53) is crucial for its oncogenic gain of function activity.
DNAJA1, a member of J-domain containing proteins or heat shock protein 40, is shown to …