[HTML][HTML] The amyloid-β oligomer hypothesis: beginning of the third decade
The amyloid-β oligomer (AβO) hypothesis was introduced in 1998. It proposed that the brain
damage leading to Alzheimer's disease (AD) was instigated by soluble, ligand-like AβOs …
damage leading to Alzheimer's disease (AD) was instigated by soluble, ligand-like AβOs …
Amyloid β oligomers in Alzheimer's disease pathogenesis, treatment, and diagnosis
Protein aggregation is common to dozens of diseases including prionoses, diabetes,
Parkinson's and Alzheimer's. Over the past 15 years, there has been a paradigm shift in …
Parkinson's and Alzheimer's. Over the past 15 years, there has been a paradigm shift in …
High molecular weight amyloid β1‐42 oligomers induce neurotoxicity via plasma membrane damage
T Yasumoto, Y Takamura, M Tsuji… - The FASEB …, 2019 - escholarship.org
Amyloid β-protein (Aβ) molecules tend to aggregate and subsequently form low MW (LMW)
oligomers, high MW (HMW) aggregates such as protofibrils, and ultimately fibrils. These Aβ …
oligomers, high MW (HMW) aggregates such as protofibrils, and ultimately fibrils. These Aβ …
Cell-membrane-mimicking lipid-coated nanoparticles confer Raman enhancement to membrane proteins and reveal membrane-attached amyloid-β conformation
Identifying the structures of membrane bound proteins is critical to understanding their
function in healthy and diseased states. We introduce a surface enhanced Raman …
function in healthy and diseased states. We introduce a surface enhanced Raman …
Structural studies of amyloid-β peptides: Unlocking the mechanism of aggregation and the associated toxicity
R Aleksis, F Oleskovs, K Jaudzems, J Pahnke… - Biochimie, 2017 - Elsevier
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases
worldwide. Formation of amyloid plaques consisting of amyloid-β peptides (Aβ) is one of the …
worldwide. Formation of amyloid plaques consisting of amyloid-β peptides (Aβ) is one of the …
Tetrameric Aβ40 and Aβ42 β-barrel structures by extensive atomistic simulations. II. In aqueous solution
PH Nguyen, JM Campanera, ST Ngo… - The Journal of …, 2019 - ACS Publications
Alzheimer's disease (AD) is characterized by the accumulation of extracellular Aβ42 and
Aβ40 oligomers and plaques. In a recent computational study, we found that the presence of …
Aβ40 oligomers and plaques. In a recent computational study, we found that the presence of …
Significant structural differences between transient amyloid‐β oligomers and less‐toxic fibrils in regions known to harbor familial alzheimer′ s mutations
Small oligomers of the amyloid β (Aβ) peptide, rather than the monomers or the fibrils, are
suspected to initiate Alzheimer′ s disease (AD). However, their low concentration and …
suspected to initiate Alzheimer′ s disease (AD). However, their low concentration and …
Aβ1-42 monomers or oligomers have different effects on autophagy and apoptosis
M Guglielmotto, D Monteleone, A Piras, V Valsecchi… - Autophagy, 2014 - Taylor & Francis
The role of autophagy and its relationship with apoptosis in Alzheimer disease (AD)
pathogenesis is poorly understood. Disruption of autophagy leads to buildup of incompletely …
pathogenesis is poorly understood. Disruption of autophagy leads to buildup of incompletely …
Simple and efficient chromophoric-fluorogenic probes for diethylchlorophosphate vapor
In this work, we developed two small-molecule probes for real-time and onsite detecting of
diethylchlorophosphate (DCP) vapor by incorporating amine groups into Schiff base …
diethylchlorophosphate (DCP) vapor by incorporating amine groups into Schiff base …
An early folding contact between Phe19 and Leu34 is critical for amyloid-β oligomer toxicity
Small hydrophobic oligomers of aggregation-prone proteins are thought to be generically
toxic. Here we examine this view by perturbing an early folding contact between Phe19 and …
toxic. Here we examine this view by perturbing an early folding contact between Phe19 and …