Cell signaling plays a key role in the development of all multicellular organisms. Numerous
studies have established the importance of Hedgehog signaling in a wide variety of …

The process of gastrulation is a pivotal step in the formation of the vertebrate body plan. The
primary function of gastrulation is the correct placement of precursor tissues for subsequent …

INTRODUCTION During embryogenesis, pluripotent cells gradually become specialized
and acquire distinct functions and morphologies. Because much of the specification process …

Zebrafish have become a popular organism for the study of vertebrate gene function,. The
virtually transparent embryos of this species, and the ability to accelerate genetic studies by …

Cell identity is governed by the complex regulation of gene expression, represented as gene-
regulatory networks. Here we use gene-regulatory networks inferred from single-cell multi …

Targeted gene disruption in the mouse shows that the Sonic hedgehog (Shh) gene plays a
critical role in patterning of vertebrate embryonic tissues, including the brain and spinal cord …

The maturation of single-cell transcriptomic technologies has facilitated the generation of
comprehensive cellular atlases from whole embryos,,–. A majority of these data, however …

Systematic genome-wide mutagenesis screens for embryonic phenotypes have been
instrumental in the understanding of invertebrate and plant development. Here, we report …

Low back pain (LBP), frequently associated with intervertebral disc (IVD) degeneration, is a
major public health concern. LBP is currently managed by pharmacological treatments and …

The notochord is the defining structure of the chordates, and has essential roles in
vertebrate development. It serves as a source of midline signals that pattern surrounding …