The second-generation thrombopoietin (TPO) receptor agonists eltrombopag and
romiplostim are potent activators of megakaryopoiesis and represent a growing treatment …

Eltrombopag, an oral thrombopoietin-receptor agonist, stimulates hematopoiesis in patients
with acquired aplastic anemia (AA) and has higher exposure in patients of East Asian origin …

Abstract Background and Objectives Eltrombopag seems to be effective in treating patients
with aplastic anemia in several clinical trials. This paper aims to perform the first meta …

Highlights•SOMAscan is an aptamer-based proteomic technology for large-scale
studies.•Nineteen serum proteins are proposed as biomarkers and prognosticators of …

Although hematopoietic growth factors are found at high levels in aplastic anemia (AA)
patients, little is known about their dynamic change over time after treatment. We examined …

Objective: To describe the current approach to diagnosis and treatment of aplastic anemia.
Methods: Review of the literature. Results: Aplastic anemia can be acquired or associated …

Activation of inflammatory pathways is associated with bone marrow failure syndromes, but
how specific molecules impact on the marrow microenvironment is not well elucidated. We …

Within the past several years, important work showed that hematopoiesis in the majority of
idiopathic acquired aplastic anemia patients is clonal, potentially reflecting selective …