Invadopodia are a subset of invadosomes that are implicated in the integration of signals
from the tumor microenvironment to support tumor cell invasion and dissemination. Recent …

Tumor metastasis is a multistep process by which tumor cells disseminate from their primary
site and form secondary tumors at a distant site. Metastasis occurs through a series of steps …

The differentiation plasticity of epithelial cells that mediates TGF-β-induced EMT and
reversion from mesenchymal to epithelial phenotype are increasingly seen as integral …

Tumor cell extravasation is a key step during cancer metastasis, yet the precise mechanisms
that regulate this dynamic process are unclear. We utilized a high-resolution time-lapse …

Transitory phenotypic changes such as the epithelial–mesenchymal transition (EMT) help
embryonic cells to generate migratory descendants that populate new sites and establish …

Metastasis of tumor cells from primary sites of malignancy to neighboring stromal tissue or
distant localities entails in several instances, but not in every case, the epithelial …

Clear cell Renal Cell Carcinoma (ccRCC) is the most common and metastatic urological
cancer. Molecular players of ccRCC progression and metastasis are not completely known …

Metastasis is responsible for most cancer-associated deaths. Accumulating evidence based
on 3D migration models has revealed a diversity of invasive migratory schemes reflecting …

Bone metastasis remains a major cause of mortality and morbidity in breast cancer.
Therefore, there is an urgent need to better select high-risk patients in order to adapt …

The ability to degrade extracellular matrix is critical for tumor cells to invade and
metastasize. Recent studies show that tumor cells use specialized actin-based membrane …