Pathobiology of Modic changes
Purpose Low back pain (LBP) is the most disabling condition worldwide. Although LBP
relates to different spinal pathologies, vertebral bone marrow lesions visualized as Modic …
relates to different spinal pathologies, vertebral bone marrow lesions visualized as Modic …
Lumbar degenerative disease part 1: anatomy and pathophysiology of intervertebral discogenic pain and radiofrequency ablation of basivertebral and sinuvertebral …
HS Kim, PH Wu, IT Jang - International journal of molecular sciences, 2020 - mdpi.com
Degenerative disc disease is a leading cause of chronic back pain in the aging population in
the world. Sinuvertebral nerve and basivertebral nerve are postulated to be associated with …
the world. Sinuvertebral nerve and basivertebral nerve are postulated to be associated with …
Modic changes of the lumbar spine: prevalence, risk factors, and association with disc degeneration and low back pain in a large-scale population-based cohort
FPS Mok, D Samartzis, J Karppinen, DYT Fong… - The spine journal, 2016 - Elsevier
Abstract Background Context Modic changes (MC) are bone marrow lesions on magnetic
resonance imaging (MRI), suggestive of being associated with low back pain (LBP). Data on …
resonance imaging (MRI), suggestive of being associated with low back pain (LBP). Data on …
Antibiotic treatment in patients with chronic low back pain and vertebral bone edema (Modic type 1 changes): a double-blind randomized clinical controlled trial of …
HB Albert, JS Sorensen, BS Christensen… - European Spine …, 2013 - Springer
Purpose Modic type 1 changes/bone edema in the vertebrae are present in 6% of the
general population and 35–40% of the low back pain population. It is strongly associated …
general population and 35–40% of the low back pain population. It is strongly associated …
Modic changes—their associations with low back pain and activity limitation: a systematic literature review and meta-analysis
C Herlin, P Kjaer, A Espeland, JS Skouen… - PloS one, 2018 - journals.plos.org
Background Previous systematic reviews have reported positive associations between
Modic changes (MCs) and low back pain (LBP), but due to their narrow scope and new …
Modic changes (MCs) and low back pain (LBP), but due to their narrow scope and new …
The American Society of Pain and Neuroscience (ASPN) evidence-based clinical guideline of interventional treatments for low back pain
D Sayed, J Grider, N Strand, JM Hagedorn… - Journal of Pain …, 2022 - Taylor & Francis
Introduction Painful lumbar spinal disorders represent a leading cause of disability in the US
and worldwide. Interventional treatments for lumbar disorders are an effective treatment for …
and worldwide. Interventional treatments for lumbar disorders are an effective treatment for …
Contribution of the endplates to disc degeneration
AJ Fields, A Ballatori, EC Liebenberg… - Current molecular biology …, 2018 - Springer
Abstract Purpose of Review The endplates form the interface between the rigid vertebral
bodies and compliant intervertebral discs. Proper endplate function involves a balance …
bodies and compliant intervertebral discs. Proper endplate function involves a balance …
ISSLS PRIZE IN BASIC SCIENCE 2017: intervertebral disc/bone marrow cross-talk with Modic changes
Study design Cross-sectional cohort analysis of patients with Modic Changes (MC).
Objective Our goal was to characterize the molecular and cellular features of MC bone …
Objective Our goal was to characterize the molecular and cellular features of MC bone …
ISSLS prize winner: vertebral endplate (Modic) change is an independent risk factor for episodes of severe and disabling low back pain
JH Määttä, S Wadge, A MacGregor, J Karppinen… - Spine, 2015 - journals.lww.com
Study Design. Longitudinal cohort study of twins representative of the general population.
Objective. To assess the relationship between Modic change (MC) and severe, disabling …
Objective. To assess the relationship between Modic change (MC) and severe, disabling …
Association between changes in lumbar Modic changes and low back symptoms over a two-year period
J Järvinen, J Karppinen, J Niinimäki, M Haapea… - BMC musculoskeletal …, 2015 - Springer
Abstract Background The association of Modic changes (MC) with low back pain (LBP) is
unclear. The purpose of our study was to investigate the associations between the extent of …
unclear. The purpose of our study was to investigate the associations between the extent of …