Loss-of-function heterozygous mutations in GRN, the gene encoding progranulin (PGRN),
were identified in patients with frontotemporal lobar degeneration (FTLD) almost two …

Prosaposin (PSAP) modulates glycosphingolipid metabolism and variants have been linked
to Parkinson's disease (PD). Here, we find altered PSAP levels in the plasma, CSF and post …

Haploinsufficiency of the progranulin protein is a leading cause of frontotemporal lobar
degeneration. Accumulating evidence support a crucial role of progranulin in the lysosome …

Heterozygous mutations in the granulin (GRN) gene, resulting in the haploinsufficiency of
the progranulin (PGRN) protein, is a leading cause of frontotemporal lobar degeneration …

Background Progranulin (PGRN) is a lysosomal glycoprotein implicated in various
neurodegenerative diseases, including frontotemporal dementia and neuronal ceroid …

Heterozygous loss-of-function mutations in the GRN gene are a major cause of hereditary
frontotemporal dementia. The mechanisms linking frontotemporal dementia pathogenesis to …

Cytoplasmic inclusions containing aberrant proteolytic fragments of TDP-43 are associated
with frontotemporal lobar degeneration (FTLD) and other related pathologies. In FTLD, TDP …

Background Neuroinflammation in the nucleus accumbens (NAc) is well known to influence
the progression of depression. However, the molecular mechanisms triggering NAc …

Loss of function progranulin (GRN) mutations are a major autosomal dominant cause of
frontotemporal dementia (FTD). Patients with FTD due to GRN mutations (FTD-GRN) …

Progranulin (PGRN) deficiency is linked to neurodegenerative diseases including
frontotemporal dementia, Alzheimer's disease, Parkinson's disease, and neuronal ceroid …