Recruitment of polycomb group complexes and their role in the dynamic regulation of cell fate choice

B Schuettengruber, G Cavalli - Development, 2009 - journals.biologists.com
Polycomb group (PcG) protein complexes dynamically define cellular identity through the
regulation of key developmental genes. Important advances in the PcG field have come from …

Environmentally induced phenotypes and DNA methylation: how to deal with unpredictable conditions until the next generation and after

B Angers, E Castonguay, R Massicotte - Molecular Ecology, 2010 - Wiley Online Library
Organisms often respond to environmental changes by producing alternative phenotypes.
Epigenetic processes such as DNA methylation may contribute to environmentally induced …

Polycomb group response elements in Drosophila and vertebrates

JA Kassis, JL Brown - Advances in genetics, 2013 - Elsevier
Polycomb group genes (PcG) encode a group of about 16 proteins that were first identified
in Drosophila as repressors of homeotic genes. PcG proteins are present in all metazoans …

Mechanisms for the inheritance of chromatin states

D Moazed - Cell, 2011 - cell.com
Studies in eukaryotes ranging from yeast to mammals indicate that specific chromatin
structures can be inherited following DNA replication via mechanisms acting in cis. Both the …

[HTML][HTML] A vertebrate Polycomb response element governs segmentation of the posterior hindbrain

A Sing, D Pannell, A Karaiskakis, K Sturgeon… - Cell, 2009 - cell.com
Chromatin remodeling by Polycomb group (PcG) and trithorax group (trxG) proteins
regulates gene expression in all metazoans. Two major complexes, Polycomb repressive …

The quest for mammalian Polycomb response elements: are we there yet?

M Bauer, J Trupke, L Ringrose - Chromosoma, 2016 - Springer
A long-standing mystery in the field of Polycomb and Trithorax regulation is how these
proteins, which are highly conserved between flies and mammals, can regulate several …

Evolutionary tinkering with conserved components of a transcriptional regulatory network

H Lavoie, H Hogues, J Mallick, A Sellam, A Nantel… - PLoS …, 2010 - journals.plos.org
Gene expression variation between species is a major contributor to phenotypic diversity,
yet the underlying flexibility of transcriptional regulatory networks remains largely …

A theoretical model of Polycomb/Trithorax action unites stable epigenetic memory and dynamic regulation

J Reinig, F Ruge, M Howard, L Ringrose - Nature communications, 2020 - nature.com
Polycomb and Trithorax group proteins maintain stable epigenetic memory of gene
expression states for some genes, but many targets show highly dynamic regulation. Here …

Epigenomic plasticity within populations: its evolutionary significance and potential

LJ Johnson, PJ Tricker - Heredity, 2010 - nature.com
Epigenetics has progressed rapidly from an obscure quirk of heredity into a data-heavy
'omic'science. Our understanding of the molecular mechanisms of epigenomic regulation …

Cooperativity, specificity, and evolutionary stability of Polycomb targeting in Drosophila

B Schuettengruber, NO Elkayam, T Sexton, M Entrevan… - Cell reports, 2014 - cell.com
Metazoan genomes are partitioned into modular chromosomal domains containing active or
repressive chromatin. In flies, Polycomb group (PcG) response elements (PREs) recruit PHO …