Structures and mechanisms of nonsegmented, negative-strand RNA virus polymerases
M Ouizougun-Oubari, R Fearns - Annual Review of Virology, 2023 - annualreviews.org
The nonsegmented, negative-strand RNA viruses (nsNSVs), also known as the order
Mononegavirales, have a genome consisting of a single strand of negative-sense RNA …
Mononegavirales, have a genome consisting of a single strand of negative-sense RNA …
[HTML][HTML] Structures of the promoter-bound respiratory syncytial virus polymerase
The respiratory syncytial virus (RSV) polymerase is a multifunctional RNA-dependent RNA
polymerase composed of the large (L) protein and the phosphoprotein (P). It transcribes the …
polymerase composed of the large (L) protein and the phosphoprotein (P). It transcribes the …
Structural basis of paramyxo-and pneumovirus polymerase inhibition by non-nucleoside small-molecule antivirals
Small-molecule antivirals can be used as chemical probes to stabilize transitory
conformational stages of viral target proteins, facilitating structural analyses. Here, we …
conformational stages of viral target proteins, facilitating structural analyses. Here, we …
Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitor
X Yu, P Abeywickrema, B Bonneux, I Behera… - Communications …, 2023 - nature.com
The respiratory syncytial virus polymerase complex, consisting of the polymerase (L) and
phosphoprotein (P), catalyzes nucleotide polymerization, cap addition, and cap methylation …
phosphoprotein (P), catalyzes nucleotide polymerization, cap addition, and cap methylation …
Conserved allosteric inhibitory site on the respiratory syncytial virus and human metapneumovirus RNA-dependent RNA polymerases
VA Kleiner, T O. Fischmann, JA Howe… - Communications …, 2023 - nature.com
Respiratory syncytial virus (RSV) and human metapneumovirus (HMPV) are related RNA
viruses responsible for severe respiratory infections and resulting disease in infants, elderly …
viruses responsible for severe respiratory infections and resulting disease in infants, elderly …
Cryo-EM structure of Nipah virus RNA polymerase complex
Y Wang, L Zhao, Y Zhang, Y Wang, J Tang, S Liu… - Science …, 2024 - science.org
Nipah virus, a member of the Paramyxoviridae family, is a highly pathogenic nonsegmented,
negative-sense RNA virus (nsNSV) which causes severe neurological and respiratory …
negative-sense RNA virus (nsNSV) which causes severe neurological and respiratory …
Structure of the Nipah virus polymerase complex
Nipah virus is a highly virulent zoonotic paramyxovirus causing severe respiratory and
neurological disease. Despite its lethality, there is no approved treatment for Nipah virus …
neurological disease. Despite its lethality, there is no approved treatment for Nipah virus …
How does the polymerase of non-segmented negative strand RNA viruses commit to transcription or genome replication?
VA Kleiner, R Fearns - Journal of Virology, 2024 - journals.asm.org
The Mononegavirales, or non-segmented negative-sense RNA viruses (nsNSVs), includes
significant human pathogens, such as respiratory syncytial virus, parainfluenza virus …
significant human pathogens, such as respiratory syncytial virus, parainfluenza virus …
Analysis of template variations on RNA synthesis by respiratory syncytial virus polymerase
D Cao, I Gooneratne, C Mera, J Vy, M Royal, B Huang… - Viruses, 2022 - mdpi.com
Respiratory syncytial virus (RSV) is a significant threat to infants and elderly individuals
globally. Currently, there are no effective therapies or treatments for RSV infection because …
globally. Currently, there are no effective therapies or treatments for RSV infection because …
[HTML][HTML] JNJ-7184, a respiratory syncytial virus inhibitor targeting the connector domain of the viral polymerase
B Bonneux, A Shareef, S Tcherniuk, B Anson… - Antiviral Research, 2024 - Elsevier
Respiratory syncytial virus (RSV) can cause pulmonary complications in infants, elderly and
immunocompromised patients. While two vaccines and two prophylactic monoclonal …
immunocompromised patients. While two vaccines and two prophylactic monoclonal …