Structures and mechanisms of nonsegmented, negative-strand RNA virus polymerases

M Ouizougun-Oubari, R Fearns - Annual Review of Virology, 2023 - annualreviews.org
The nonsegmented, negative-strand RNA viruses (nsNSVs), also known as the order
Mononegavirales, have a genome consisting of a single strand of negative-sense RNA …

[HTML][HTML] Structures of the promoter-bound respiratory syncytial virus polymerase

D Cao, Y Gao, Z Chen, I Gooneratne, C Roesler… - Nature, 2024 - nature.com
The respiratory syncytial virus (RSV) polymerase is a multifunctional RNA-dependent RNA
polymerase composed of the large (L) protein and the phosphoprotein (P). It transcribes the …

Structural basis of paramyxo-and pneumovirus polymerase inhibition by non-nucleoside small-molecule antivirals

JD Wolf, MR Sirrine, RM Cox… - Antimicrobial Agents and …, 2024 - journals.asm.org
Small-molecule antivirals can be used as chemical probes to stabilize transitory
conformational stages of viral target proteins, facilitating structural analyses. Here, we …

Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitor

X Yu, P Abeywickrema, B Bonneux, I Behera… - Communications …, 2023 - nature.com
The respiratory syncytial virus polymerase complex, consisting of the polymerase (L) and
phosphoprotein (P), catalyzes nucleotide polymerization, cap addition, and cap methylation …

Conserved allosteric inhibitory site on the respiratory syncytial virus and human metapneumovirus RNA-dependent RNA polymerases

VA Kleiner, T O. Fischmann, JA Howe… - Communications …, 2023 - nature.com
Respiratory syncytial virus (RSV) and human metapneumovirus (HMPV) are related RNA
viruses responsible for severe respiratory infections and resulting disease in infants, elderly …

Cryo-EM structure of Nipah virus RNA polymerase complex

Y Wang, L Zhao, Y Zhang, Y Wang, J Tang, S Liu… - Science …, 2024 - science.org
Nipah virus, a member of the Paramyxoviridae family, is a highly pathogenic nonsegmented,
negative-sense RNA virus (nsNSV) which causes severe neurological and respiratory …

Structure of the Nipah virus polymerase complex

E Balıkçı, F Günl, L Carrique, JR Keown, E Fodor… - The EMBO …, 2024 - embopress.org
Nipah virus is a highly virulent zoonotic paramyxovirus causing severe respiratory and
neurological disease. Despite its lethality, there is no approved treatment for Nipah virus …

How does the polymerase of non-segmented negative strand RNA viruses commit to transcription or genome replication?

VA Kleiner, R Fearns - Journal of Virology, 2024 - journals.asm.org
The Mononegavirales, or non-segmented negative-sense RNA viruses (nsNSVs), includes
significant human pathogens, such as respiratory syncytial virus, parainfluenza virus …

Analysis of template variations on RNA synthesis by respiratory syncytial virus polymerase

D Cao, I Gooneratne, C Mera, J Vy, M Royal, B Huang… - Viruses, 2022 - mdpi.com
Respiratory syncytial virus (RSV) is a significant threat to infants and elderly individuals
globally. Currently, there are no effective therapies or treatments for RSV infection because …

[HTML][HTML] JNJ-7184, a respiratory syncytial virus inhibitor targeting the connector domain of the viral polymerase

B Bonneux, A Shareef, S Tcherniuk, B Anson… - Antiviral Research, 2024 - Elsevier
Respiratory syncytial virus (RSV) can cause pulmonary complications in infants, elderly and
immunocompromised patients. While two vaccines and two prophylactic monoclonal …