Parietal cells are responsible for gastric acid secretion, which aids in the digestion of food,
absorption of minerals, and control of harmful bacteria. However, a fine balance of activators …

Recent studies have explored the function of N-linked glycosylation in the nervous system,
demonstrating essential roles of carbohydrate structures in neural development. The …

The human ether-à-go-go-related gene (HERG) encodes the pore-forming subunit of the
rapidly activating delayed rectifier potassium channel in the heart. We previously showed …

Background & Aims: Gastric H+ secretion via the H+/K+-adenosine triphosphatase is
coupled to the uptake of K+. However, the molecular identity of luminal K+ channels …

Epithelial cells of the gastrointestinal tract are an important barrier between the “milieu
interne” and the luminal content of the gut. They perform transport of nutrients, salts, and …

Recently, we and others have shown that luminal K+ recycling via KCNQ1 K+ channels is
required for gastric H+ secretion. Inhibition of KCNQ1 by the chromanol 293B strongly …

Control and modulation of electrical signaling is vital to normal physiology, particularly in
neurons, cardiac myocytes, and skeletal muscle. The orchestrated activities of variable sets …

TRPM8 is a member of the transient receptor potential ion channel superfamily, which is
expressed in sensory neurons and is activated by cold and cooling compounds, such as …

We identified a consensus N-linked glycosylation motif within the pore-forming loop between
the fifth and sixth transmembrane segments of the osmoresponsive transient receptor …

The structural variations among extracellular N-glycans reflect the activity of
glycosyltransferases and glycosidases that operate in the Golgi apparatus. More than other …