Quantitative phase imaging: recent advances and expanding potential in biomedicine

TL Nguyen, S Pradeep, RL Judson-Torres, J Reed… - ACS …, 2022 - ACS Publications
Quantitative phase imaging (QPI) is a label-free, wide-field microscopy approach with
significant opportunities for biomedical applications. QPI uses the natural phase shift of light …

Gradient light interference microscopy for 3D imaging of unlabeled specimens

TH Nguyen, ME Kandel, M Rubessa… - Nature …, 2017 - nature.com
Multiple scattering limits the contrast in optical imaging of thick specimens. Here, we present
gradient light interference microscopy (GLIM) to extract three-dimensional information from …

Solving inverse scattering problems in biological samples by quantitative phase imaging

T Kim, R Zhou, LL Goddard… - Laser & Photonics …, 2016 - Wiley Online Library
Quantitative phase imaging (QPI), a method that precisely recovers the wavefront of an
electromagnetic field scattered by a transparent, weakly scattering object, is a rapidly …

White-light diffraction tomography of unlabelled live cells

T Kim, R Zhou, M Mir, SD Babacan, PS Carney… - Nature …, 2014 - nature.com
We present a technique called white-light diffraction tomography (WDT) for imaging
microscopic transparent objects such as live unlabelled cells. The approach extends …

Comparative study of iterative reconstruction algorithms for missing cone problems in optical diffraction tomography

JW Lim, KR Lee, KH Jin, S Shin, SE Lee, YK Park… - Optics express, 2015 - opg.optica.org
In optical tomography, there exist certain spatial frequency components that cannot be
measured due to the limited projection angles imposed by the numerical aperture of …

High-resolution three-dimensional imaging of red blood cells parasitized by Plasmodium falciparum and in situ hemozoin crystals using optical diffraction …

K Kim, HO Yoon, M Diez-Silva, M Dao… - … of biomedical optics, 2014 - spiedigitallibrary.org
We present high-resolution optical tomographic images of human red blood cells (RBC)
parasitized by malaria-inducing Plasmodium falciparum (Pf)-RBCs. Three-dimensional (3-D) …

Quantitative phase imaging

M Mir, B Bhaduri, R Wang, R Zhu, G Popescu - Progress in optics, 2012 - Elsevier
Quantitative phase imaging (QPI) is an emerging field aimed at studying weakly scattering
and absorbing specimens (Popescu, 2011). The main challenge in generating intrinsic …

Diffraction phase microscopy with white light

B Bhaduri, H Pham, M Mir, G Popescu - Optics letters, 2012 - opg.optica.org
We present white light diffraction phase microscopy (wDPM) as a quantitative phase
imaging method that combines the single shot measurement benefit associated with off-axis …

Maskless imaging of dense samples using pixel super-resolution based multi-height lensfree on-chip microscopy

A Greenbaum, A Ozcan - Optics express, 2012 - opg.optica.org
Lensfree in-line holographic microscopy offers sub-micron resolution over a large field-of-
view (eg,~ 24 mm^ 2) with a cost-effective and compact design suitable for field use …

Measurement of Single Cell Refractive Index, Dry Mass, Volume, and Density<? format?> Using a Transillumination Microscope

KG Phillips, SL Jacques, OJT McCarty - Physical review letters, 2012 - APS
Phase contrast microscopy has become ubiquitous in the field of biology, particularly in
qualitative investigations of cellular morphology. However, the use of quantitative phase …