The organization of microtubule networks is crucial for controlling chromosome segregation
during cell division, for positioning and transport of different organelles, and for cell polarity …

Microtubules are cytoskeletal filaments essential for numerous aspects of cell physiology.
They are polarized polymeric tubes with a fast growing plus end and a slow growing minus …

Human oocytes are prone to assembling meiotic spindles with unstable poles, which can
favor aneuploidy in human eggs. The underlying causes of spindle instability are unknown …

Centriolar satellites comprise cytoplasmic granules that are located around the centrosome.
Their molecular identification was first reported more than a quarter of a century ago. These …

During eukaryote cell division, molecular motors are crucial regulators of microtubule
organization, spindle assembly, chromosome segregation and intracellular transport. The …

The centrosome linker joins the two interphase centrosomes of a cell into one microtubule
organizing center. Despite increasing knowledge on linker components, linker diversity in …

The cell orchestrates the dance of chromosome segregation with remarkable speed and
fidelity. The mitotic spindle is built from scratch after interphase through microtubule (MT) …

Cancer is a devastating disease that claims over 8 million lives each year. Understanding
the molecular etiology of the disease is critical to identify and develop new therapeutic …

Due to cell-cycle dysregulation, many cancer cells contain more than the normal compliment
of centrosomes, a state referred to as centrosome amplification (CA). CA can drive …

Microtubule organization has a crucial role in regulating cell architecture. The geometry of
microtubule arrays strongly depends on the distribution of sites responsible for microtubule …