Talin has emerged as the key cytoplasmic protein that mediates integrin adhesion to the
extracellular matrix. In this Review, we draw on experiments performed in mammalian cells …

In their roles as major adhesion receptors, integrins signal across the plasma membrane in
both directions. Recent structural and cell biological data suggest models for how integrins …

Control of integrin affinity for ligands (integrin activation) is essential for normal cell
adhesion, migration, and assembly of an extracellular matrix. Integrin activation is usually …

Integrins are cell surface transmembrane receptors that recognize and bind to extracellular
matrix proteins and counter receptors. Binding of activated integrins to their ligands induces …

Integrins are transmembrane cell–adhesion molecules that carry signals from the outside to
the inside of the cell and vice versa. Like other cell surface receptors, integrins signal in …

To migrate, a cell first extends protrusions such as lamellipodia and filopodia, forms
adhesions, and finally retracts its tail. The actin cytoskeleton plays a major role in this …

▪ Abstract The conversion of physical signals, such as contractile forces or external
mechanical perturbations, into chemical signaling events is a fundamental cellular process …

The activation of leukocyte integrins through diverse receptors results in transformation of
the integrin from a bent, resting form to an extended conformation, which has at least two …

The plasma membrane and the underlying cortical actin cytoskeleton undergo continuous
dynamic interplay that is responsible for many essential aspects of cell physiology …

Nectins and nectin-like molecules (Necls) are immunoglobulin-like transmembrane cell
adhesion molecules that are expressed in various cell types. Homophilic and heterophilic …