Engineered human blood–brain barrier microfluidic model for vascular permeability analyses
The blood–brain barrier (BBB) greatly restricts the entry of biological and engineered
therapeutic molecules into the brain. Due to challenges in translating results from animal …
therapeutic molecules into the brain. Due to challenges in translating results from animal …
Biology and models of the blood–brain barrier
The blood–brain barrier (BBB) is one of the most selective endothelial barriers. An
understanding of its cellular, morphological, and biological properties in health and disease …
understanding of its cellular, morphological, and biological properties in health and disease …
[HTML][HTML] Microfluidic platforms for cell cultures and investigations
This review covers several aspects of microfluidic devices used for culturing and monitoring
of both adherent and non-adherent cells, including a multitude of applications. A comparison …
of both adherent and non-adherent cells, including a multitude of applications. A comparison …
A 'print–pause–print'protocol for 3D printing microfluidics using multimaterial stereolithography
Methods to make microfluidic chips using 3D printers have attracted much attention because
these simple procedures allow rapid fabrication of ready-to-use products from digital 3D …
these simple procedures allow rapid fabrication of ready-to-use products from digital 3D …
Micropatterned neurovascular interface to mimic the blood–brain barrier's neurophysiology and micromechanical function: a BBB-on-CHIP model
AV Singh, V Chandrasekar, P Laux, A Luch, SP Dakua… - Cells, 2022 - mdpi.com
A hybrid blood–brain barrier (BBB)-on-chip cell culture device is proposed in this study by
integrating microcontact printing and perfusion co-culture to facilitate the study of BBB …
integrating microcontact printing and perfusion co-culture to facilitate the study of BBB …
A microfluidic 3D endothelium-on-a-chip model to study transendothelial migration of T cells in health and disease
L de Haan, J Suijker, R van Roey, N Berges… - International Journal of …, 2021 - mdpi.com
The recruitment of T cells is a crucial component in the inflammatory cascade of the body.
The process involves the transport of T cells through the vascular system and their stable …
The process involves the transport of T cells through the vascular system and their stable …
A microfluidic platform for functional testing of cancer drugs on intact tumor slices
AD Rodriguez, LF Horowitz, K Castro, H Kenerson… - Lab on a Chip, 2020 - pubs.rsc.org
Present approaches to assess cancer treatments are often inaccurate, costly, and/or
cumbersome. Functional testing platforms that use live tumor cells are a promising tool both …
cumbersome. Functional testing platforms that use live tumor cells are a promising tool both …
3D-Printed electrochemical sensor-integrated transwell systems
P Ramiah Rajasekaran, AA Chapin, DN Quan… - Microsystems & …, 2020 - nature.com
This work presents a 3D-printed, modular, electrochemical sensor-integrated transwell
system for monitoring cellular and molecular events in situ without sample extraction or …
system for monitoring cellular and molecular events in situ without sample extraction or …
Fitting tissue chips and microphysiological systems into the grand scheme of medicine, biology, pharmacology, and toxicology
DE Watson, R Hunziker… - Experimental biology and …, 2017 - journals.sagepub.com
Microphysiological systems (MPS), which include engineered organoids (EOs), single
organ/tissue chips (TCs), and multiple organs interconnected to create miniature in vitro …
organ/tissue chips (TCs), and multiple organs interconnected to create miniature in vitro …
Microfluidics for interrogating live intact tissues
LF Horowitz, AD Rodriguez, T Ray… - Microsystems & …, 2020 - nature.com
The intricate microarchitecture of tissues–the “tissue microenvironment”–is a strong
determinant of tissue function. Microfluidics offers an invaluable tool to precisely stimulate …
determinant of tissue function. Microfluidics offers an invaluable tool to precisely stimulate …