Engineered human blood–brain barrier microfluidic model for vascular permeability analyses

C Hajal, GS Offeddu, Y Shin, S Zhang, O Morozova… - Nature protocols, 2022 - nature.com
The blood–brain barrier (BBB) greatly restricts the entry of biological and engineered
therapeutic molecules into the brain. Due to challenges in translating results from animal …

Biology and models of the blood–brain barrier

C Hajal, B Le Roi, RD Kamm… - Annual review of …, 2021 - annualreviews.org
The blood–brain barrier (BBB) is one of the most selective endothelial barriers. An
understanding of its cellular, morphological, and biological properties in health and disease …

[HTML][HTML] Microfluidic platforms for cell cultures and investigations

ML Coluccio, G Perozziello, N Malara, E Parrotta… - Microelectronic …, 2019 - Elsevier
This review covers several aspects of microfluidic devices used for culturing and monitoring
of both adherent and non-adherent cells, including a multitude of applications. A comparison …

A 'print–pause–print'protocol for 3D printing microfluidics using multimaterial stereolithography

YT Kim, A Ahmadianyazdi, A Folch - Nature protocols, 2023 - nature.com
Methods to make microfluidic chips using 3D printers have attracted much attention because
these simple procedures allow rapid fabrication of ready-to-use products from digital 3D …

Micropatterned neurovascular interface to mimic the blood–brain barrier's neurophysiology and micromechanical function: a BBB-on-CHIP model

AV Singh, V Chandrasekar, P Laux, A Luch, SP Dakua… - Cells, 2022 - mdpi.com
A hybrid blood–brain barrier (BBB)-on-chip cell culture device is proposed in this study by
integrating microcontact printing and perfusion co-culture to facilitate the study of BBB …

A microfluidic 3D endothelium-on-a-chip model to study transendothelial migration of T cells in health and disease

L de Haan, J Suijker, R van Roey, N Berges… - International Journal of …, 2021 - mdpi.com
The recruitment of T cells is a crucial component in the inflammatory cascade of the body.
The process involves the transport of T cells through the vascular system and their stable …

A microfluidic platform for functional testing of cancer drugs on intact tumor slices

AD Rodriguez, LF Horowitz, K Castro, H Kenerson… - Lab on a Chip, 2020 - pubs.rsc.org
Present approaches to assess cancer treatments are often inaccurate, costly, and/or
cumbersome. Functional testing platforms that use live tumor cells are a promising tool both …

3D-Printed electrochemical sensor-integrated transwell systems

P Ramiah Rajasekaran, AA Chapin, DN Quan… - Microsystems & …, 2020 - nature.com
This work presents a 3D-printed, modular, electrochemical sensor-integrated transwell
system for monitoring cellular and molecular events in situ without sample extraction or …

Fitting tissue chips and microphysiological systems into the grand scheme of medicine, biology, pharmacology, and toxicology

DE Watson, R Hunziker… - Experimental biology and …, 2017 - journals.sagepub.com
Microphysiological systems (MPS), which include engineered organoids (EOs), single
organ/tissue chips (TCs), and multiple organs interconnected to create miniature in vitro …

Microfluidics for interrogating live intact tissues

LF Horowitz, AD Rodriguez, T Ray… - Microsystems & …, 2020 - nature.com
The intricate microarchitecture of tissues–the “tissue microenvironment”–is a strong
determinant of tissue function. Microfluidics offers an invaluable tool to precisely stimulate …