Endothelial cells (EC) form a unique signal-transducing surface in the vascular system. The
abundance of ion channels in the plasma membrane of these nonexcitable cells has raised …

The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the
blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in …

Blood flow and blood pressure are determined by an integration of reflex, humoral, and local
vascular control mechanisms. Knowledge of these mechanisms has mushroomed over the …

The three subtypes of calcium‐activated potassium channels (KCa) of large, intermediate
and small conductance (BKCa, IKCa and SKCa) are present in the vascular wall. In healthy …

The endothelium has the capacity to modulate vascular structure in response to
hemodynamic stimuli. We tested the hypothesis that exposure of the endothelium to …

An endothelium‐derived hyperpolarizing factor (EDHF) that is distinct from nitric oxide (NO)
and prostanoids has been widely hypothesized to hyperpolarize and relax vascular smooth …

▪ Abstract The functional impact of ion channels in vascular endothelial cells (ECs) is still a
matter of controversy. This review describes different types of ion channels in ECs and their …

It is becoming increasingly evident that electrical signaling via gap junctions plays a central
role in the physiological control of vascular tone via two related mechanisms (1) the …

Key points Endothelial inwardly rectifying K+ (Kir2. 1) channels regulate flow‐induced
vasodilatation via nitric oxide (NO) in mouse mesenteric resistance arteries. Deficiency of …

In rat mesenteric artery, endothelium-derived hyperpolarizing factor (EDHF) is blocked by a
combination of apamin and charybdotoxin (ChTX). The site of action of these toxins has not …