One hundred years ago, Ramón y Cajal, considered by many as the founder of modern
neuroscience, stated that neurons of the adult central nervous system (CNS) are incapable …

Critical roles for EPH receptor (EPH)–ephrin signalling in a range of chronic and
regenerative diseases are increasingly being recognized. In particular, the complex roles of …

Glial scarring following severe tissue damage and inflammation after spinal cord injury (SCI)
is due to an extreme, uncontrolled form of reactive astrogliosis that typically occurs around …

Abstract… once the development was ended, the founts of growth and regeneration of the
axons and dendrites dried up irrevocably. Santiago Ramón y Cajal Cajal's neurotropic …

Studies have found that molecular targets that regulate tissue development are also
involved in regulating tissue regeneration. Erythropoietin-producing hepatocyte A4 (EphA4) …

At least two-thirds of spinal cord injury cases are anatomically incomplete, without complete
spinal cord transection, although the initial injuries cause complete loss of sensory and …

Blocking the action of inhibitory molecules at sites of central nervous system injury has been
proposed as a strategy to promote axonal regeneration and functional recovery. We have …

Spinal cord injuries (SCI) are neuropathologies causing enormous physical and emotional
anguish as well as irreversibly disabilities with great socio/economic burdens to our society …

The lack of axonal regeneration in the adult central nervous system is in part attributable to
the presence of inhibitory molecules present in the environment of injured axons such as the …

Spinal cord injuries (SCI) are disastrous neuropathologies causing permanent disabilities.
The availability of different strains of mice is valuable for studying the pathophysiological …