The cGAS–STING pathway and cancer
N Samson, A Ablasser - Nature Cancer, 2022 - nature.com
The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway has
emerged as a critical innate immune pathway that, following engagement by DNA, promotes …
emerged as a critical innate immune pathway that, following engagement by DNA, promotes …
Targeting the DNA damage response in immuno-oncology: developments and opportunities
Immunotherapy has revolutionized cancer treatment and substantially improved patient
outcome with regard to multiple tumour types. However, most patients still do not benefit …
outcome with regard to multiple tumour types. However, most patients still do not benefit …
KDM5B promotes immune evasion by recruiting SETDB1 to silence retroelements
Tumours use various strategies to evade immune surveillance,. Immunotherapies targeting
tumour immune evasion such as immune checkpoint blockade have shown considerable …
tumour immune evasion such as immune checkpoint blockade have shown considerable …
[HTML][HTML] The long and short non-coding RNAs modulating EZH2 signaling in cancer
S Mirzaei, MH Gholami, K Hushmandi… - Journal of hematology & …, 2022 - Springer
Non-coding RNAs (ncRNAs) are a large family of RNA molecules with no capability in
encoding proteins. However, they participate in developmental and biological processes …
encoding proteins. However, they participate in developmental and biological processes …
Radiation therapy enhances immunotherapy response in microsatellite stable colorectal and pancreatic adenocarcinoma in a phase II trial
AR Parikh, A Szabolcs, JN Allen, JW Clark, JY Wo… - Nature cancer, 2021 - nature.com
Overcoming intrinsic resistance to immune checkpoint blockade for microsatellite stable
(MSS) colorectal cancer (CRC) and pancreatic ductal adenocarcinoma (PDAC) remains …
(MSS) colorectal cancer (CRC) and pancreatic ductal adenocarcinoma (PDAC) remains …
Inflammatory microenvironment remodelling by tumour cells after radiotherapy
M McLaughlin, EC Patin, M Pedersen, A Wilkins… - Nature Reviews …, 2020 - nature.com
The development of immune checkpoint inhibitors (ICIs) is revolutionizing the way we think
about cancer treatment. Even so, for most types of cancer, only a minority of patients …
about cancer treatment. Even so, for most types of cancer, only a minority of patients …
The cytosolic DNA-sensing cGAS–STING pathway in cancer
J Kwon, SF Bakhoum - Cancer discovery, 2020 - AACR
The recognition of DNA as an immune-stimulatory molecule is an evolutionarily conserved
mechanism to initiate rapid innate immune responses against microbial pathogens. The …
mechanism to initiate rapid innate immune responses against microbial pathogens. The …
[HTML][HTML] Regulation of RIG-I-like receptor-mediated signaling: interaction between host and viral factors
K Onomoto, K Onoguchi, M Yoneyama - Cellular & molecular …, 2021 - nature.com
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are RNA sensor molecules that
play essential roles in innate antiviral immunity. Among the three RLRs encoded by the …
play essential roles in innate antiviral immunity. Among the three RLRs encoded by the …
NIR‐II responsive inorganic 2D nanomaterials for cancer photothermal therapy: recent advances and future challenges
Non‐invasive cancer photothermal therapy (PTT) is a promising replacement for traditional
cancer treatments. The second near‐infrared region induced PTT (NIR‐II PTT, 1000–1500 …
cancer treatments. The second near‐infrared region induced PTT (NIR‐II PTT, 1000–1500 …
EZH2 inhibition activates a dsRNA–STING–interferon stress axis that potentiates response to PD-1 checkpoint blockade in prostate cancer
Prostate cancers are considered to be immunologically 'cold'tumors given the very few
patients who respond to checkpoint inhibitor (CPI) therapy. Recently, enrichment of …
patients who respond to checkpoint inhibitor (CPI) therapy. Recently, enrichment of …