Clinical insights into small cell lung cancer: Tumor heterogeneity, diagnosis, therapy, and future directions

Z Megyesfalvi, CM Gay, H Popper… - CA: a cancer journal …, 2023 - Wiley Online Library
Small cell lung cancer (SCLC) is characterized by rapid growth and high metastatic capacity.
It has strong epidemiologic and biologic links to tobacco carcinogens. Although the majority …

Immunotherapy in lung cancer: current landscape and future directions

H Mamdani, S Matosevic, AB Khalid, G Durm… - Frontiers in …, 2022 - frontiersin.org
Over the past decade, lung cancer treatment has undergone a major paradigm shift. A
greater understanding of lung cancer biology has led to the development of many effective …

A neutrophil response linked to tumor control in immunotherapy

J Gungabeesoon, NA Gort-Freitas, M Kiss, E Bolli… - Cell, 2023 - cell.com
Neutrophils accumulate in solid tumors, and their abundance correlates with poor prognosis.
Neutrophils are not homogeneous, however, and could play different roles in cancer …

Current treatments for non-small cell lung cancer

Q Guo, L Liu, Z Chen, Y Fan, Y Zhou, Z Yuan… - Frontiers in …, 2022 - frontiersin.org
Despite improved methods of diagnosis and the development of different treatments,
mortality from lung cancer remains surprisingly high. Non-small cell lung cancer (NSCLC) …

Evolving role of immunotherapy in small cell lung cancer

ED Barrows, MJ Blackburn, SV Liu - Seminars in Cancer Biology, 2022 - Elsevier
Small cell lung cancer (SCLC) is a highly lethal subtype of lung cancer with a particularly
poor prognosis. For decades, the best available systemic therapy was platinum plus …

SCLC treatment in the immuno-oncology era: current evidence and unmet needs

L Belluomini, L Calvetti, A Inno, G Pasello… - Frontiers in …, 2022 - frontiersin.org
Small cell lung cancer (SCLC) represents about 13%–15% of all lung cancers. It has a
particularly unfavorable prognosis and in about 70% of cases occurs in the advanced stage …

[HTML][HTML] Challenges in the treatment of small cell lung cancer in the era of immunotherapy and molecular classification

E Caliman, S Fancelli, G Petroni, MRG Michelet… - Lung Cancer, 2023 - Elsevier
For many years the standard of care for small cell lung cancer (SCLC) has remained
unchanged. Despite decades of active research, current treatment options are limited and …

[HTML][HTML] Durvalumab with chemoradiotherapy for limited-stage small-cell lung cancer

S Park, JM Noh, YL Choi, SA Chi, K Kim… - European Journal of …, 2022 - Elsevier
Background The current standard treatment for limited-stage small-cell lung cancer (LS-
SCLC) is chemotherapy with concurrent chemoradiotherapy (CCRT). Methods In this single …

Global research landscape and trends of lung cancer immunotherapy: a bibliometric analysis

Y Liu, X Cheng, X Han, X Cheng, S Jiang… - Frontiers in …, 2022 - frontiersin.org
​ Background Immunotherapy for lung cancer has been a hot research area for years. This
bibliometric analysis aims to present the research trends on lung cancer immunotherapy …

SEOM-GECP Clinical guidelines for diagnosis, treatment and follow-up of small-cell lung cancer (SCLC)(2022)

R García-Campelo, I Sullivan, E Arriola, A Insa… - Clinical and …, 2023 - Springer
Small-cell lung cancer (SCLC) is a highly aggressive malignancy comprising approximately
15% of lung cancers. Only one-third of patients are diagnosed at limited-stage (LS). Surgical …