Chalcones are among the leading bioactive flavonoids with a therapeutic potential
implicated to an array of bioactivities investigated by a series of preclinical and clinical …

Medicinal chemists continue to be fascinated by chalcone derivatives because of their
simple chemistry, ease of hydrogen atom manipulation, straightforward synthesis, and a …

Chalcones (1, 3-diaryl-2-propen-1-ones) are open chain flavonoids that are widely
biosynthesized in plants. They are important for the pigmentation of flowers and, hence, act …

Microtubules play an important role in the process of cell mitosis and can form a spindle in
the mitotic prophase of the cell, which can pull chromosomes to the ends of the cell and then …

Pyrazolines display a broad spectrum of potential pharmacological activities and are present
in a number of pharmacologically active molecules such as phenazone/amidopyrene …

There is an emerging paradigm shift in oncology that seeks to emphasize molecularly
targeted approaches for cancer prevention and therapy. Chalcones (1, 3-diphenyl-2-propen …

Besides 2′, 4′-dihydroxy-4, 6′-dimethoxy-3′-prenylchalcone (1) and 4-acetoxy-2′,
4′-dihydroxy-6′-methoxy-3′-prenylchalkon (2), both phase II metabolites of xanthohumol …

Since microtubules have an important role in mitosis and other vital cellular functions,
tubulin-targeting chemotherapy has been received growing attention in anticancer drug …

A new efficient copper-catalyzed intramolecular amination reaction has been developed to
readily synthesise a wide variety of multi-substituted 2H-indazole and 1H-pyrazole …

Cancer is the world's second-largest cause of mortality and one of the biggest global health
concerns. The prevalence and mortality rates of cancer remain high despite significant …