Evolution of Drug-Resistant Mycobacterium tuberculosis Strains and Their Adaptation to the Human Lung Environment

A Allué-Guardia, JI García, JB Torrelles - Frontiers in Microbiology, 2021 - frontiersin.org
In the last two decades, multi (MDR), extensively (XDR), extremely (XXDR) and total (TDR)
drug-resistant Mycobacterium tuberculosis (M. tb) strains have emerged as a threat to public …

The cGAS-STING pathway in bacterial infection and bacterial immunity

N Liu, X Pang, H Zhang, P Ji - Frontiers in immunology, 2022 - frontiersin.org
Cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP)(cGAMP)
synthase (cGAS), along with the adaptor stimulator of interferon genes (STING), are crucial …

Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice

CM Smith, RE Baker, MK Proulx, BB Mishra, JE Long… - Elife, 2022 - elifesciences.org
The outcome of an encounter with Mycobacterium tuberculosis (Mtb) depends on the
pathogen's ability to adapt to the variable immune pressures exerted by the host …

[HTML][HTML] Systemic immune dysregulation in severe tuberculosis patients revealed by a single-cell transcriptome atlas

Y Wang, Q Sun, Y Zhang, X Li, Q Liang, R Guo… - Journal of Infection, 2023 - Elsevier
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) infection, is currently the
deadliest infectious disease in human that can evolve to severe forms. A comprehensive …

Interaction of mycobacteria with host cell inflammasomes

S Rastogi, V Briken - Frontiers in Immunology, 2022 - frontiersin.org
The inflammasome complex is important for host defense against intracellular bacterial
infections. Mycobacterium tuberculosis (Mtb) is a facultative intracellular bacterium which is …

Gene evolutionary trajectories in Mycobacterium tuberculosis reveal temporal signs of selection

A Chiner-Oms, MG López… - Proceedings of the …, 2022 - National Acad Sciences
Genetic differences between different Mycobacterium tuberculosis complex (MTBC) strains
determine their ability to transmit within different host populations, their latency times, and …

Origin and Global Expansion of Mycobacterium tuberculosis Complex Lineage 3

YA Shuaib, C Utpatel, TA Kohl, I Barilar, M Diricks… - Genes, 2022 - mdpi.com
Simple Summary Tuberculosis still causes 1.5 million deaths annually and is mainly caused
by Mycobacterium tuberculosis complex strains belonging to three evolutionary modern …

Advances on the Role and Applications of Interleukin-1 in Tuberculosis

D Silvério, R Gonçalves, R Appelberg, M Saraiva - MBio, 2021 - Am Soc Microbiol
ABSTRACT Interleukin-1 (IL-1) is a key player in the immune response to pathogens due to
its role in promoting inflammation and recruiting immune cells to the site of infection. In …

Ethambutol and meropenem/clavulanate synergy promotes enhanced extracellular and intracellular killing of Mycobacterium tuberculosis

F Olivença, D Pires, C Silveiro, B Gama… - Antimicrobial Agents …, 2024 - Am Soc Microbiol
Increasing evidence supports the repositioning of beta-lactams for tuberculosis (TB) therapy,
but further research on their interaction with conventional anti-TB agents is still warranted …

Animal models for COVID-19 and tuberculosis

B Corleis, M Bastian, D Hoffmann, M Beer… - Frontiers in …, 2023 - frontiersin.org
Respiratory infections cause tremendous morbidity and mortality worldwide. Amongst these
diseases, tuberculosis (TB), a bacterial illness caused by Mycobacterium tuberculosis which …