Evolution of Drug-Resistant Mycobacterium tuberculosis Strains and Their Adaptation to the Human Lung Environment
A Allué-Guardia, JI García, JB Torrelles - Frontiers in Microbiology, 2021 - frontiersin.org
In the last two decades, multi (MDR), extensively (XDR), extremely (XXDR) and total (TDR)
drug-resistant Mycobacterium tuberculosis (M. tb) strains have emerged as a threat to public …
drug-resistant Mycobacterium tuberculosis (M. tb) strains have emerged as a threat to public …
The cGAS-STING pathway in bacterial infection and bacterial immunity
N Liu, X Pang, H Zhang, P Ji - Frontiers in immunology, 2022 - frontiersin.org
Cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP)(cGAMP)
synthase (cGAS), along with the adaptor stimulator of interferon genes (STING), are crucial …
synthase (cGAS), along with the adaptor stimulator of interferon genes (STING), are crucial …
Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice
The outcome of an encounter with Mycobacterium tuberculosis (Mtb) depends on the
pathogen's ability to adapt to the variable immune pressures exerted by the host …
pathogen's ability to adapt to the variable immune pressures exerted by the host …
[HTML][HTML] Systemic immune dysregulation in severe tuberculosis patients revealed by a single-cell transcriptome atlas
Y Wang, Q Sun, Y Zhang, X Li, Q Liang, R Guo… - Journal of Infection, 2023 - Elsevier
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) infection, is currently the
deadliest infectious disease in human that can evolve to severe forms. A comprehensive …
deadliest infectious disease in human that can evolve to severe forms. A comprehensive …
Interaction of mycobacteria with host cell inflammasomes
The inflammasome complex is important for host defense against intracellular bacterial
infections. Mycobacterium tuberculosis (Mtb) is a facultative intracellular bacterium which is …
infections. Mycobacterium tuberculosis (Mtb) is a facultative intracellular bacterium which is …
Gene evolutionary trajectories in Mycobacterium tuberculosis reveal temporal signs of selection
A Chiner-Oms, MG López… - Proceedings of the …, 2022 - National Acad Sciences
Genetic differences between different Mycobacterium tuberculosis complex (MTBC) strains
determine their ability to transmit within different host populations, their latency times, and …
determine their ability to transmit within different host populations, their latency times, and …
Origin and Global Expansion of Mycobacterium tuberculosis Complex Lineage 3
Simple Summary Tuberculosis still causes 1.5 million deaths annually and is mainly caused
by Mycobacterium tuberculosis complex strains belonging to three evolutionary modern …
by Mycobacterium tuberculosis complex strains belonging to three evolutionary modern …
Advances on the Role and Applications of Interleukin-1 in Tuberculosis
D Silvério, R Gonçalves, R Appelberg, M Saraiva - MBio, 2021 - Am Soc Microbiol
ABSTRACT Interleukin-1 (IL-1) is a key player in the immune response to pathogens due to
its role in promoting inflammation and recruiting immune cells to the site of infection. In …
its role in promoting inflammation and recruiting immune cells to the site of infection. In …
Ethambutol and meropenem/clavulanate synergy promotes enhanced extracellular and intracellular killing of Mycobacterium tuberculosis
Increasing evidence supports the repositioning of beta-lactams for tuberculosis (TB) therapy,
but further research on their interaction with conventional anti-TB agents is still warranted …
but further research on their interaction with conventional anti-TB agents is still warranted …
Animal models for COVID-19 and tuberculosis
B Corleis, M Bastian, D Hoffmann, M Beer… - Frontiers in …, 2023 - frontiersin.org
Respiratory infections cause tremendous morbidity and mortality worldwide. Amongst these
diseases, tuberculosis (TB), a bacterial illness caused by Mycobacterium tuberculosis which …
diseases, tuberculosis (TB), a bacterial illness caused by Mycobacterium tuberculosis which …