For the past few years there has been an exponential increase in the use of animal models
to confirm the pathogenicity of candidate disease-causing genetic variants found in patients …

The zebrafish is a powerful toxicity model; biochemical assays can be combined with
observations at a structural and functional level within one individual. This mini review …

Genetically encoded voltage indicators (GEVIs) enable monitoring of neuronal activity at
high spatial and temporal resolution. However, the utility of existing GEVIs has been limited …

In order to localize the neural circuits involved in generating behaviors, it is necessary to
assign activity onto anatomical maps of the nervous system. Using brain registration across …

Understanding brain-wide neuronal dynamics requires a detailed map of the underlying
circuit architecture. We built an interactive cellular-resolution atlas of the zebrafish brain at 6 …

A fundamental question in neuroscience is how entire neural circuits generate behaviour
and adapt it to changes in sensory feedback. Here we use two-photon calcium imaging to …

In the absence of salient sensory cues to guide behavior, animals must still execute
sequences of motor actions in order to forage and explore. How such successive motor …

To track and control self-location, animals integrate their movements through space.
Representations of self-location are observed in the mammalian hippocampal formation, but …

Ancient DNA research has been revolutionized following development of next-generation
sequencing platforms. Although a number of such platforms have been applied to ancient …

The advent of multimodal brain atlases promises to accelerate progress in neuroscience by
allowing in silico queries of neuron morphology, connectivity, and gene expression. We …