The NADPH Link between the Renin Angiotensin System and the Antioxidant Mechanisms in Dopaminergic Neurons

R Franco, J Serrano-Marín, G Navarro… - Antioxidants, 2023 - mdpi.com
The renin angiotensin system (RAS) has several components including signaling peptides,
enzymes, and membrane receptors. The effort in characterizing this system in the periphery …

Dopaminergic axons: key recitalists in Parkinson's disease

AK Mishra, A Dixit - Neurochemical Research, 2022 - Springer
Parkinson's disease (PD) is associated with dopamine depletion in the striatum owing to the
selective and progressive loss of the nigrostriatal dopaminergic neurons, which results in …

Comparative analysis of Parkinson's disease–associated genes in mice reveals altered survival and bioenergetics of Parkin-deficient dopamine neurons

N Giguère, C Pacelli, C Saumure, MJ Bourque… - Journal of Biological …, 2018 - ASBMB
Many mutations in genes encoding proteins such as Parkin, PTEN-induced putative kinase
1 (PINK1), protein deglycase DJ-1 (DJ-1 or PARK7), leucine-rich repeat kinase 2 (LRRK2) …

Neonatal 6‐OHDA lesion of the SNc induces striatal compensatory sprouting from surviving SNc dopaminergic neurons without VTA contribution

W Tanguay, C Ducrot, N Giguère… - European Journal of …, 2021 - Wiley Online Library
Dopamine (DA) neurons of the substantia nigra pars compacta (SNc) are uniquely
vulnerable to neurodegeneration in Parkinson's disease (PD). We hypothesize that their …

[HTML][HTML] Four main therapeutic keys for Parkinson's disease: A mini review

D Hernandez-Baltazar, R Nadella… - Iranian Journal of …, 2019 - ncbi.nlm.nih.gov
Objective (s): Parkinson's disease (PD) is characterized by motor and cognitive dysfunctions.
The progressive degeneration of dopamine-producing neurons that are present in the …

In vivo and in vitro approaches to characterising axon growth and metabolic alterations in Parkinson's disease

M Travaglio - 2023 - repository.cam.ac.uk
A recent pathological hypothesis of Parkinson's disease suggests that at the time of disease
onset, midbrain dopaminergic cells lose their synaptic connectivity before dying. The …

[HTML][HTML] La taille de l'axone est un facteur majeur influençant la dépense énergétique et la vulnérabilité des neurones dopaminergiques dans la maladie de Parkinson

N Giguère, LÉ Trudeau - médecine/sciences, 2016 - medecinesciences.org
La taille de l’axone est un facteur majeur influençant la dépense énergétique et la vulnérabilité
des neurones dopaminergiques dans la maladie de Parkinson | médecine/sciences EDP …

Elektrophysiologische Charakterisierung der Locus coeruleus Neuronen von Parkin-Knockout Mäusen mit Hilfe der Patch-Clamp-Technik

AK Müller - archiv.ub.uni-marburg.de
Die Parkinson-Erkrankung (engl. Parkinson's Disease) gilt als zweit häufigste
neurodegenerative Erkrankung weltweit nach der Alzheimer-Erkrankung. Die Hälfte aller …