The tumor microenvironment is proposed to contribute substantially to the progression of
cancers, including breast cancer. Cancer‐associated fibroblasts (CAFs) are the most …

Simple Summary Stroma modifications observed in solid cancer are now recognized as
critical events for cancer progression and as potential therapeutic or diagnostic targets. The …

Tumor cells exist in close proximity with non-malignant cells. Extensive and multilayered
crosstalk between tumor cells and stromal cells tailors the tumor microenvironment (TME) to …

Spatial transcriptomics (ST) technology through in situ capturing has enabled topographical
gene expression profiling of tumor tissues. However, each capturing spot may contain …

Metastasis or the progression of malignancy poses a major challenge in cancer therapy and
is the principal reason for increased mortality. The epithelial-mesenchymal transition (EMT) …

Increasing evidence shows that hepatocellular carcinoma (HCC) is a principal cause of
cancer-related mortality globally, especially among Asian and African populations. Collagen …

Simple Summary Cancer cells rely on the surrounding environment to grow and spread.
This environment contains structural components, secreted factors, immune cells, and other …

The tumor extracellular matrix (ECM) plays a vital role in tumor progression and drug
resistance. Previous studies have shown that breast tissue-derived matrices could be an …

Cancers are complex ecosystems composed of malignant cells embedded in an intricate
microenvironment made of different non-transformed cell types and extracellular matrix …

Despite advances in cancer detection and therapy, it has been estimated that the incidence
of cancers will increase, while the mortality rate will continue to remain high, a fact explained …