The inflammation is the protective response of the body against various harmful stimuli;
however, the aberrant and inappropriate activation tends to become harmful. The acute …

Gene therapy, which involves replacement of a defective gene with a functional, healthy
copy of that gene, is a potentially beneficial cancer treatment approach particularly over …

BACKGROUND: MicroRNAs (miRNAs) are small noncoding RNAs that regulate the
expression of approximately 60% of all human genes. They play important roles in …

The “holy grail” of cancer therapy is to identify and exploit genetic elements and signal
transduction pathways capable of selectively destroying tumor cells without eliciting harmful …

In this study, we report the efficacy of RGD (arginine-glycine-aspartic acid) peptide-modified
polylactic acid-co-glycolic acid (PLGA)-Chitosan nanoparticle (CSNP) for integrin αvβ3 …

The melanoma differentiation-associated gene-7 (mda-7; approved gene symbol IL24) is a
tumor suppressor gene whose expression induces selective apoptosis in tumor cells. To …

The mda-7 gene (approved gene symbol IL24) is a novel tumor suppressor gene with tumor-
apoptotic and immune-activating properties. We completed a Phase I dose-escalation …

The blood and lymphatic vasculature have an important role in skin homeostasis.
Angiogenesis and lymphangiogenesis—the growth of new vessels from existing ones …

Abstract Interleukin-22 (IL-22) is an IL-10 family cytokine produced by T cells and innate
lymphoid cells. The IL-22 signaling pathway orchestrates mucosal immune defense and …

First identified almost two decades ago as a novel gene differentially expressed in human
melanoma cells induced to terminally differentiate, MDA-7/IL-24 has since shown great …