Eukaryotic fertilization and gamete fusion at a glance

Y Lu, M Ikawa - Journal of Cell Science, 2022 - journals.biologists.com
In sexually reproducing organisms, the genetic information is transmitted from one
generation to the next via the merger of male and female gametes. Gamete fusion is a two …

The viral class II membrane fusion machinery: divergent evolution from an ancestral heterodimer

P Guardado-Calvo, FA Rey - Viruses, 2021 - mdpi.com
A key step during the entry of enveloped viruses into cells is the merger of viral and cell lipid
bilayers. This process is driven by a dedicated membrane fusion protein (MFP) present at …

DMP8 and 9 regulate HAP2/GCS1 trafficking for the timely acquisition of sperm fusion competence

W Wang, H Xiong, P Cyprys, R Malka… - Proceedings of the …, 2022 - National Acad Sciences
Sexual reproduction involves the fusion of two gametes of opposite sex. Although the sperm-
expressed fusogen HAPLESS 2 (HAP2) or GENERATIVE CELL SPECIFIC 1 (GCS1) plays a …

Divergent molecular signatures in fish Bouncer proteins define cross-fertilization boundaries

KRB Gert, K Panser, J Surm, BS Steinmetz… - Nature …, 2023 - nature.com
Molecular compatibility between gametes is a prerequisite for successful fertilization. As
long as a sperm and egg can recognize and bind each other via their surface proteins …

Fusexins, HAP2/GCS1 and evolution of gamete fusion

NG Brukman, X Li, B Podbilewicz - Frontiers in Cell and …, 2022 - frontiersin.org
Gamete fusion is the climax of fertilization in all sexually reproductive organisms, from
unicellular fungi to humans. Similarly to other cell-cell fusion events, gamete fusion is …

HAP2-mediated gamete fusion: lessons from the world of unicellular eukaryotes

JF Pinello, TG Clark - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
Most, if not all the cellular requirements for fertilization and sexual reproduction arose early
in evolution and are retained in extant lineages of single-celled organisms including a …

Behavior of Male Gamete Fusogen GCS1/HAP2 and the Regulation in Arabidopsis Double Fertilization

Y Shiba, T Takahashi, Y Ohashi, M Ueda, A Mimuro… - Biomolecules, 2023 - mdpi.com
In the sexual reproduction of flowering plants, two independent fertilization events occur
almost simultaneously: two identical sperm cells fuse with either the egg cell or the central …

SPE-51, a sperm-secreted protein with an immunoglobulin-like domain, is required for fertilization in C. elegans

X Mei, KA Maniates, AR Krauchunas, M Druzhinina… - Current Biology, 2023 - cell.com
Fertilization is a fundamental process in sexual reproduction during which gametes fuse to
combine their genetic material and start the next generation in their life cycle. Fertilization …

Uncovering an ancestral green ménage à trois: Contributions of Chlamydomonas to the discovery of a broadly conserved triad of plant fertilization proteins

WJ Snell - Current opinion in plant biology, 2022 - Elsevier
During sexual reproduction in the unicellular green alga Chlamydomonas, gametes
undergo the conserved cellular events that define fertilization across the tree of life. After …

Metal organic layers enabled cell surface engineering coupling biomembrane fusion for dynamic membrane proteome profiling

Q Jiang, H Wang, Z Qiao, Y Hou, Z Sui, B Zhao… - Chemical …, 2023 - pubs.rsc.org
Systematically dissecting the highly dynamic and tightly communicating membrane
proteome of living cells is essential for the system-level understanding of fundamental …