Targeting signalling pathways and the immune microenvironment of cancer stem cells—a clinical update
Cancer stem cells (CSCs) have important roles in tumour development, relapse and
metastasis; the intrinsic self-renewal characteristics and tumorigenic properties of these cells …
metastasis; the intrinsic self-renewal characteristics and tumorigenic properties of these cells …
Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update
N Takebe, L Miele, PJ Harris, W Jeong… - Nature reviews Clinical …, 2015 - nature.com
During the past decade, cancer stem cells (CSCs) have been increasingly identified in many
malignancies. Although the origin and plasticity of these cells remain controversial, tumour …
malignancies. Although the origin and plasticity of these cells remain controversial, tumour …
Randomized phase Ib/II study of gemcitabine plus placebo or vismodegib, a hedgehog pathway inhibitor, in patients with metastatic pancreatic cancer
DVT Catenacci, MR Junttila, T Karrison… - Journal of Clinical …, 2015 - ascopubs.org
Purpose Sonic hedgehog (SHH), an activating ligand of smoothened (SMO), is
overexpressed in> 70% of pancreatic cancers (PCs). We investigated the impact of …
overexpressed in> 70% of pancreatic cancers (PCs). We investigated the impact of …
Pancreatic cancer: from state-of-the-art treatments to promising novel therapies
I Garrido-Laguna, M Hidalgo - Nature reviews Clinical oncology, 2015 - nature.com
Pancreatic cancer is expected to be the second deadliest malignancy in the USA by 2020.
The survival rates for patients with other gastrointestinal malignancies have increased …
The survival rates for patients with other gastrointestinal malignancies have increased …
Pilot clinical trial of hedgehog pathway inhibitor GDC-0449 (vismodegib) in combination with gemcitabine in patients with metastatic pancreatic adenocarcinoma
Purpose: The hedgehog (HH) signaling pathway is a key regulator in tumorigenesis of
pancreatic adenocarcinoma and is upregulated in pancreatic adenocarcinoma cancer stem …
pancreatic adenocarcinoma and is upregulated in pancreatic adenocarcinoma cancer stem …
A phase I study of FOLFIRINOX plus IPI-926, a hedgehog pathway inhibitor, for advanced pancreatic adenocarcinoma
AH Ko, N LoConte, MA Tempero, EJ Walker… - Pancreas, 2016 - journals.lww.com
Objectives In mouse models of pancreatic cancer, IPI-926, an oral Hedgehog inhibitor,
increases chemotherapy delivery by depleting tumor-associated stroma. This multicenter …
increases chemotherapy delivery by depleting tumor-associated stroma. This multicenter …
Chemotherapy and radiotherapy for advanced pancreatic cancer
Background Pancreatic cancer (PC) is a highly lethal disease with few effective treatment
options. Over the past few decades, many anti‐cancer therapies have been tested in the …
options. Over the past few decades, many anti‐cancer therapies have been tested in the …
[HTML][HTML] Perspectives in the treatment of pancreatic adenocarcinoma
A Cid-Arregui, V Juarez - World journal of gastroenterology: WJG, 2015 - ncbi.nlm.nih.gov
Pancreatic ductal adenocarcinoma (PDAC) is an incurable lethal disease whose incidence
rate is growing. There is no effective screening for detection of early stage tumors and, in …
rate is growing. There is no effective screening for detection of early stage tumors and, in …
The epithelial to mesenchymal transition in pancreatic cancer: A systematic review
Abstract Background/Objectives The present article summarizes and analyzes the current
knowledge about the role of the epithelial to mesenchymal transition (EMT) in the systemic …
knowledge about the role of the epithelial to mesenchymal transition (EMT) in the systemic …
Fibroblasts in liver cancer: functions and therapeutic translation
Accumulation of fibroblasts in the premalignant or malignant liver is a characteristic feature
of liver cancer, but has not been therapeutically leveraged despite evidence for …
of liver cancer, but has not been therapeutically leveraged despite evidence for …