COVID-19 presents significant social, economic, and medical challenges. Because COVID-
19 has already begun to precipitate huge increases in mental health problems, clinical …

Bipolar Disorder | New England Journal of Medicine Skip to main content The New England
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Abstract Purpose of Review Bipolar disorder has the highest rate of suicide of all psychiatric
conditions and is approximately 20–30 times that of the general population. The purpose of …

Bipolar disorders (BD) represent a severe leading disabling mental condition worldwide
characterized by episodic and often progressive mood fluctuations with manic and …

Unpredictable chronic mild stress (UCMS) is one of the most commonly used, robust and
translatable models for studying the neurobiological basis of major depression. Although the …

Applied psychopharmacotherapy and psychotherapy do not always bring the expected
results in the treatment of mental disorders. As a result, other interventions are receiving …

Accumulating evidence indicates that patients with severe mental disorders, including major
depression, bipolar disorder and schizophrenia present with various alterations of the gut …

Obesity is an emerging condition, with a prevalence of~ 20%. Although the simple
measurement of BMI is likely a simplistic approach to obesity, BMI is easily calculated, and …

The number of the elderly across the globe will approximate 2.1 billion by 2050. Juxtaposed
against this burgeoning segment of the population is evidence that nonpathological aging is …

Bipolar disorder (BD) is strongly associated with immune dysfunction. Replicated
epidemiological studies have demonstrated that BD has high rates of inflammatory medical …