Heart failure with preserved ejection fraction: mechanisms, clinical features, and therapies
The clinical syndrome comprising heart failure (HF) symptoms but with a left ventricular
ejection fraction (EF) that is not diminished, eg, HF with preserved EF, is increasingly the …
ejection fraction (EF) that is not diminished, eg, HF with preserved EF, is increasingly the …
Nitric oxide synthases in heart failure
R Carnicer, MJ Crabtree, V Sivakumaran… - Antioxidants & redox …, 2013 - liebertpub.com
Significance: The regulation of myocardial function by constitutive nitric oxide synthases
(NOS) is important for the maintenance of myocardial Ca2+ homeostasis, relaxation and …
(NOS) is important for the maintenance of myocardial Ca2+ homeostasis, relaxation and …
Molecular and cellular basis for diastolic dysfunction
L van Heerebeek, CPM Franssen, N Hamdani… - Current heart failure …, 2012 - Springer
Heart failure with preserved ejection fraction (HFpEF) is highly prevalent and is frequently
associated with metabolic risk factors. Patients with HFpEF have only a slightly lower …
associated with metabolic risk factors. Patients with HFpEF have only a slightly lower …
Nanodomain regulation of cardiac cyclic nucleotide signaling by phosphodiesterases
K Kokkonen, DA Kass - Annual review of pharmacology and …, 2017 - annualreviews.org
Cyclic nucleotide phosphodiesterases (PDEs) form an 11-member superfamily comprising
100 different isoforms that regulate the second messengers cyclic adenosine or guanosine …
100 different isoforms that regulate the second messengers cyclic adenosine or guanosine …
Maturation, inactivation, and recovery mechanisms of soluble guanylyl cyclase
Soluble guanylate cyclase (sGC) is a heme-containing heterodimeric enzyme that generates
many molecules of cGMP in response to its ligand nitric oxide (NO); sGC thereby acts as an …
many molecules of cGMP in response to its ligand nitric oxide (NO); sGC thereby acts as an …
Old dog, new tricks: novel cardiac targets and stress regulation by protein kinase G
The second messenger cyclic guanosine 3′ 5′ monophosphate (cGMP) and its
downstream effector protein kinase G (PKG) have been discovered more than 40 years ago …
downstream effector protein kinase G (PKG) have been discovered more than 40 years ago …
Pathophysiological basis for nutraceutical supplementation in heart failure: a comprehensive review
There is evidence demonstrating that heart failure (HF) occurs in 1–2% of the global
population and is often accompanied by comorbidities which contribute to increasing the …
population and is often accompanied by comorbidities which contribute to increasing the …
Redox regulation of soluble guanylyl cyclase
RC Shah, S Sanker, KC Wood, BG Durgin, AC Straub - Nitric oxide, 2018 - Elsevier
The nitric oxide/soluble guanylyl cyclase (NO-sGC) signaling pathway regulates the
cardiovascular, neuronal, and gastrointestinal systems. Impaired sGC signaling can result in …
cardiovascular, neuronal, and gastrointestinal systems. Impaired sGC signaling can result in …
Prevention of PKG1α oxidation augments cardioprotection in the stressed heart
The cGMP-dependent protein kinase-1α (PKG1α) transduces NO and natriuretic peptide
signaling; therefore, PKG1α activation can benefit the failing heart. Disease modifiers such …
signaling; therefore, PKG1α activation can benefit the failing heart. Disease modifiers such …
Phosphodiesterase 9a inhibition in mouse models of diastolic dysfunction
M Methawasin, J Strom, T Borkowski… - Circulation: Heart …, 2020 - Am Heart Assoc
Background: Low myocardial cGMP-PKG (cyclic guanosine monophosphate-protein kinase
G) activity has been associated with increased cardiomyocyte diastolic stiffness in heart …
G) activity has been associated with increased cardiomyocyte diastolic stiffness in heart …